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Background and Objectives The combined intratympanic and oral steroid treatment hasbeen accepted as effective treatment strategy for idiopathic sudden sensorineural hearing loss(ISSNHL). However, the treatment protocol of combined treatment for ISSNHL has not been established. In this study, we investigated whether hearing outcome differed according to differentstarting timing of intratympanic steroid injection (ITSI) in combined treatment for ISSNHL. Subjects and Method Tertiary academic referral center-based retrospective medical recordsof idiopathic 144 ISSNHL patients who received combined treatment from January2015 to April 2018 were reviewed. All patients underwent a 2-week oral systemic steroidtreatment and multiple ITSI. The hearing results of 3 months after treatment were comparedaccording to the timing of ITSI. Results The mean pure tone audiogram gain was 24.3±23.6 dB. When Siegel’s criteria wasapplied, the overall rate of hearing improvement was 63.9% (92/144). The rate of hearing improvementwas significantly higher in women (p=0.043) statistically, and there was a statisticallysignificant lower rate of recovery in the former history of hearing loss (p＜0.01) or otitismedia (p＜0.01). Moreover, the shorter the delay between symptom onset and initial ITSI,greater the statistical significance of hearing recovery rate became (p＜0.01). Conclusion The result of this study suggests that early ITSI during combined intratympanicand oral steroid treatment increases the chance of hearing recovery.
