@article{ART002636315,
author={박현식 and 신현빈 and 이명신 and 김주헌 and 김선영 and 박진성},
title={Seminal Vesicle Involvement by Carcinoma In Situ of the Bladder: Clonal Analysis Using Next-Generation Sequencing to Elucidate the Mechanism of Tumor Spread},
journal={Cancer Research and Treatment},
issn={1598-2998},
year={2020},
volume={52},
number={4},
pages={1283-1287},
doi={10.4143/crt.2020.002}
}

TY - JOUR
AU - 박현식
AU - 신현빈
AU - 이명신
AU - 김주헌
AU - 김선영
AU - 박진성
TI - Seminal Vesicle Involvement by Carcinoma In Situ of the Bladder: Clonal Analysis Using Next-Generation Sequencing to Elucidate the Mechanism of Tumor Spread
T2 - Cancer Research and Treatment
JO - Cancer Research and Treatment
PY - 2020
VL - 52
IS - 4
PB - 대한암학회
SP - 1283
EP - 1287
SN - 1598-2998
AB - We present a rare case of urothelial carcinoma in situ (CIS), which invades the prostate and seminal vesicle (SV). A 70-year-old man underwent transurethral resection of bladder (TURB), and the pathologic examination revealed multiple CIS. Although the patient received intravesical bacillus Calmette-Guerin (BCG) therapy following TURB, recurrence of CIS was confirmed in the bladder and left distal ureter at 3 months following BCG. Radical cystectomy was performed due to BCG-refractory CIS. Microscopically, CIS was found throughout the mucosa of the bladder, left ureter, prostatic duct, and both SVs. Next-generation sequencing revealed significant differences in tumor clonality between bladder and SV CIS cells. Among 101 (bladder CIS) and 95 (SV CIS) somatic mutations, only two were shared, and only one gene (ARHGAP23) was common exon coding region gene. In conclusion, multicentric genetic changes, in line with the field-cancerization effect, may result in SV involvement by CIS of the bladder.
KW - Urinary bladder neoplasms, Seminal vesicle involvement, Carcinoma-in-situ, High-throughput nucleotide sequencing, Clonality
DO - 10.4143/crt.2020.002
ER -

박현식, 신현빈, 이명신, 김주헌, 김선영 and 박진성. 2020, "Seminal Vesicle Involvement by Carcinoma In Situ of the Bladder: Clonal Analysis Using Next-Generation Sequencing to Elucidate the Mechanism of Tumor Spread", Cancer Research and Treatment, vol.52, no.4 pp.1283-1287. Available from: doi:10.4143/crt.2020.002

박현식, 신현빈, 이명신, 김주헌, 김선영, 박진성 "Seminal Vesicle Involvement by Carcinoma In Situ of the Bladder: Clonal Analysis Using Next-Generation Sequencing to Elucidate the Mechanism of Tumor Spread" Cancer Research and Treatment 52.4 pp.1283-1287 (2020) : 1283.

박현식, 신현빈, 이명신, 김주헌, 김선영, 박진성. Seminal Vesicle Involvement by Carcinoma In Situ of the Bladder: Clonal Analysis Using Next-Generation Sequencing to Elucidate the Mechanism of Tumor Spread. 2020; 52(4), 1283-1287. Available from: doi:10.4143/crt.2020.002

박현식, 신현빈, 이명신, 김주헌, 김선영 and 박진성. "Seminal Vesicle Involvement by Carcinoma In Situ of the Bladder: Clonal Analysis Using Next-Generation Sequencing to Elucidate the Mechanism of Tumor Spread" Cancer Research and Treatment 52, no.4 (2020) : 1283-1287.doi: 10.4143/crt.2020.002

박현식; 신현빈; 이명신; 김주헌; 김선영; 박진성. Seminal Vesicle Involvement by Carcinoma In Situ of the Bladder: Clonal Analysis Using Next-Generation Sequencing to Elucidate the Mechanism of Tumor Spread. Cancer Research and Treatment, 52(4), 1283-1287. doi: 10.4143/crt.2020.002

박현식; 신현빈; 이명신; 김주헌; 김선영; 박진성. Seminal Vesicle Involvement by Carcinoma In Situ of the Bladder: Clonal Analysis Using Next-Generation Sequencing to Elucidate the Mechanism of Tumor Spread. Cancer Research and Treatment. 2020; 52(4) 1283-1287. doi: 10.4143/crt.2020.002

박현식, 신현빈, 이명신, 김주헌, 김선영, 박진성. Seminal Vesicle Involvement by Carcinoma In Situ of the Bladder: Clonal Analysis Using Next-Generation Sequencing to Elucidate the Mechanism of Tumor Spread. 2020; 52(4), 1283-1287. Available from: doi:10.4143/crt.2020.002

박현식, 신현빈, 이명신, 김주헌, 김선영 and 박진성. "Seminal Vesicle Involvement by Carcinoma In Situ of the Bladder: Clonal Analysis Using Next-Generation Sequencing to Elucidate the Mechanism of Tumor Spread" Cancer Research and Treatment 52, no.4 (2020) : 1283-1287.doi: 10.4143/crt.2020.002