@article{ART002580821,
author={오둘리 and 김유진 and 조아라 and 임소정 and 김초은 and 정명아 and 신자원 and 강휴원 and 최은진 and 김재용 and 최철웅},
title={Antidepressant-like and Hypnotic Effects of the Herbal Extract Combination of Stauntonia hexaphylla and Vaccinium bracteatum Fruit in Mice},
journal={동의생리병리학회지},
issn={1738-7698},
year={2020},
volume={34},
number={2},
pages={88-96}
}

TY - JOUR
AU - 오둘리
AU - 김유진
AU - 조아라
AU - 임소정
AU - 김초은
AU - 정명아
AU - 신자원
AU - 강휴원
AU - 최은진
AU - 김재용
AU - 최철웅
TI - Antidepressant-like and Hypnotic Effects of the Herbal Extract Combination of Stauntonia hexaphylla and Vaccinium bracteatum Fruit in Mice
T2 - 동의생리병리학회지
JO - 동의생리병리학회지
PY - 2020
VL - 34
IS - 2
PB - 한의병리학회
SP - 88
EP - 96
SN - 1738-7698
AB - Stauntonia hexaphylla (SH) and Vaccinium bracteatum (VB) are herbal extracts widely used in food and traditional herbal medicine, and have the ability to perform a wide range of biological activities. We aimed to investigate the effects of the SH and VB combination (SHVB) on mice models of chronic restraint stress (CRS) and pentobarbital-induced sleeping behaviors to elucidate its possible mechanisms of action. CRS-exposed mice treated with SHVB showed significantly decreased immobility time, increased swimming and climbing times in the forced swim test (FST), and increased locomotor activity in the open field test (OFT). SHVB decreased serum CORT levels, but enhanced brain monoamine neurotransmitters. SHVB significantly decreased the sleep latency and increased total sleep duration in pentobarbital-induced sleeping behavior in mice. SHVB showed inhibitory effect on 5-HT2A receptor-mediated ERK1/2 phosphorylation. These results suggest that SHVB has antidepressant and hypnotic effects by regulating the 5-HT2A receptor.
KW - Stauntonia hexaphylla, Vaccinium bracteatum, Chronic restraint stress, Antidepressants, Serotonin 2A receptor
DO -
UR -
ER -

오둘리, 김유진, 조아라, 임소정, 김초은, 정명아, 신자원, 강휴원, 최은진, 김재용 and 최철웅. 2020, "Antidepressant-like and Hypnotic Effects of the Herbal Extract Combination of Stauntonia hexaphylla and Vaccinium bracteatum Fruit in Mice", 동의생리병리학회지, vol.34, no.2 pp.88-96.

오둘리, 김유진, 조아라, 임소정, 김초은, 정명아, 신자원, 강휴원, 최은진, 김재용, 최철웅 "Antidepressant-like and Hypnotic Effects of the Herbal Extract Combination of Stauntonia hexaphylla and Vaccinium bracteatum Fruit in Mice" 동의생리병리학회지 34.2 pp.88-96 (2020) : 88.

오둘리, 김유진, 조아라, 임소정, 김초은, 정명아, 신자원, 강휴원, 최은진, 김재용, 최철웅. Antidepressant-like and Hypnotic Effects of the Herbal Extract Combination of Stauntonia hexaphylla and Vaccinium bracteatum Fruit in Mice. 2020; 34(2), 88-96.

오둘리, 김유진, 조아라, 임소정, 김초은, 정명아, 신자원, 강휴원, 최은진, 김재용 and 최철웅. "Antidepressant-like and Hypnotic Effects of the Herbal Extract Combination of Stauntonia hexaphylla and Vaccinium bracteatum Fruit in Mice" 동의생리병리학회지 34, no.2 (2020) : 88-96.

오둘리; 김유진; 조아라; 임소정; 김초은; 정명아; 신자원; 강휴원; 최은진; 김재용; 최철웅. Antidepressant-like and Hypnotic Effects of the Herbal Extract Combination of Stauntonia hexaphylla and Vaccinium bracteatum Fruit in Mice. 동의생리병리학회지, 34(2), 88-96.

오둘리; 김유진; 조아라; 임소정; 김초은; 정명아; 신자원; 강휴원; 최은진; 김재용; 최철웅. Antidepressant-like and Hypnotic Effects of the Herbal Extract Combination of Stauntonia hexaphylla and Vaccinium bracteatum Fruit in Mice. 동의생리병리학회지. 2020; 34(2) 88-96.

오둘리, 김유진, 조아라, 임소정, 김초은, 정명아, 신자원, 강휴원, 최은진, 김재용, 최철웅. Antidepressant-like and Hypnotic Effects of the Herbal Extract Combination of Stauntonia hexaphylla and Vaccinium bracteatum Fruit in Mice. 2020; 34(2), 88-96.

오둘리, 김유진, 조아라, 임소정, 김초은, 정명아, 신자원, 강휴원, 최은진, 김재용 and 최철웅. "Antidepressant-like and Hypnotic Effects of the Herbal Extract Combination of Stauntonia hexaphylla and Vaccinium bracteatum Fruit in Mice" 동의생리병리학회지 34, no.2 (2020) : 88-96.