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Purpose: To characterize associated reactions (ARs) in the contralateral arm across multiple muscles during unimanual tasksand to identify factors related to ARs in children with cerebral palsy (CP). Materials and Methods: This was a prospective, cross-sectional study of 35 children with CP. The extent of ARs of the contra-lateral,non-task hand was assessed while performing three unimanual tasks (opening and clenching the fist, a finger oppositiontask, and tapping fingers). The occurrence of ARs in each trial was evaluated separately for each task using a four-point scale (totalscores ranged from 0 to 12). Surface electromyography (SEMG) was used to measure the firing activity of the muscles of the oppositearm during the task. The Manual Ability Classification System and Melbourne Assessment 2 (MA-2) were used to evaluateupper limb function. Results: AR scores were higher in the more-affected limb than in the less-affected limb. SEMG data on the non-task hand showedmotor overflow up to the elbow muscles in the more-affected limb. Root mean square ratios of EMG signals were significantly higherin children with ARs than in children without ARs. Multiple regression analysis showed both age and MA-2 to be significant factorsrelated to ARs in the more-affected limb. Conclusion: Children with visible ARs showed motor overflow in the non-task limb during unimanual hand tasks. Age and upperlimb function were significantly related to the extent of ARs in the more-affected limb of children with CP.