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This study was to investigate the effects of an aerobic exercise with different intensities on neuronal plasticity-related protein expression in brain of obese rats. At 4 weeks of age, S.D rats(N=40) were randomly assigned to : high fat diet control group(HF-C, n=10), high fat diet+low intensity exercise group(HF+LE, n=10), high fat diet+moderate intensity exercise group(HF+ME, n=10) and high fat diet+high intensity exercise group(HF+HE, n=10). Rats in the exercise group run on a treadmill at a speed of HF+LE group(8~10m/min), HF+ME(14~16m/min), HF+HE(20~22m/min) for 60 min daily (30-40 min/day) for 8 weeks. After 8 weeks treadmill exercise, serum total cholesterol, LDL-C, triglyceride level were significantly decreased in exercise groups compared with HF-C group(p<.05) and then HDL-C was significantly increased in exercise groups compared with HF-C group(p<.05). In the hippocampus, BDNF mRNA and VEGF mRNA expression were significantly increased in exercise groups compared with HF-C group(p<.05). IGF-1 mRNA and escape latency were non significantly diffrent in exercise groups compared with HFC group. These results showed that 8 weeks treadmill exercise training can improve serum lipid and neuronal plasticityrelated protein expression of hippocampus in obese rats.
