@article{ART002518851,
author={Qian Zhang and Changpeng Hu and Jingbin Huang and Wuyi Liu and Wenjing Lai and Faning Leng and Qin Tang and Yali Liu and Qing Wang and Min Zhou and Fangfang Sheng and Guobing Li and Rong Zhang},
title={ROCK1 induces dopaminergic nerve cell apoptosis via the activation of Drp1-mediated aberrant mitochondrial fission in Parkinson’s disease},
journal={Experimental and Molecular Medicine},
issn={1226-3613},
year={2019},
volume={51},
pages={1-13}
}

TY - JOUR
AU - Qian Zhang
AU - Changpeng Hu
AU - Jingbin Huang
AU - Wuyi Liu
AU - Wenjing Lai
AU - Faning Leng
AU - Qin Tang
AU - Yali Liu
AU - Qing Wang
AU - Min Zhou
AU - Fangfang Sheng
AU - Guobing Li
AU - Rong Zhang
TI - ROCK1 induces dopaminergic nerve cell apoptosis via the activation of Drp1-mediated aberrant mitochondrial fission in Parkinson’s disease
T2 - Experimental and Molecular Medicine
JO - Experimental and Molecular Medicine
PY - 2019
VL - 51
IS - null
PB - 생화학분자생물학회
SP - 1
EP - 13
SN - 1226-3613
AB - Dopamine deficiency is mainly caused by apoptosis of dopaminergic nerve cells in the substantia nigra of themidbrain and the striatum and is an important pathologic basis of Parkinson’s disease (PD). Recent research has shownthat dynamin-related protein 1 (Drp1)-mediated aberrant mitochondrial fission plays a crucial role in dopaminergicnerve cell apoptosis. However, the upstream regulatory mechanism remains unclear. Our study showed that Drp1knockdown inhibited aberrant mitochondrial fission and apoptosis. Importantly, we found that ROCK1 was activated inan MPP+-induced PD cell model and that ROCK1 knockdown and the specific ROCK1 activation inhibitor Y-27632blocked Drp1-mediated aberrant mitochondrial fission and apoptosis of dopaminergic nerve cells by suppressing Drp1dephosphorylation/activation. Our in vivo study confirmed that Y-27632 significantly improved symptoms in a PDmouse model by inhibiting Drp1-mediated aberrant mitochondrial fission and apoptosis. Collectively, our findingssuggest an important molecular mechanism of PD pathogenesis involving ROCK1-regulated dopaminergic nerve cellapoptosis via the activation of Drp1-induced aberrant mitochondrial fission.
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Qian Zhang, Changpeng Hu, Jingbin Huang, Wuyi Liu, Wenjing Lai, Faning Leng, Qin Tang, Yali Liu, Qing Wang, Min Zhou, Fangfang Sheng, Guobing Li and Rong Zhang. 2019, "ROCK1 induces dopaminergic nerve cell apoptosis via the activation of Drp1-mediated aberrant mitochondrial fission in Parkinson’s disease", Experimental and Molecular Medicine, vol.51, pp.1-13.

Qian Zhang, Changpeng Hu, Jingbin Huang, Wuyi Liu, Wenjing Lai, Faning Leng, Qin Tang, Yali Liu, Qing Wang, Min Zhou, Fangfang Sheng, Guobing Li, Rong Zhang "ROCK1 induces dopaminergic nerve cell apoptosis via the activation of Drp1-mediated aberrant mitochondrial fission in Parkinson’s disease" Experimental and Molecular Medicine 51 pp.1-13 (2019) : 1.

Qian Zhang, Changpeng Hu, Jingbin Huang, Wuyi Liu, Wenjing Lai, Faning Leng, Qin Tang, Yali Liu, Qing Wang, Min Zhou, Fangfang Sheng, Guobing Li, Rong Zhang. ROCK1 induces dopaminergic nerve cell apoptosis via the activation of Drp1-mediated aberrant mitochondrial fission in Parkinson’s disease. 2019; 51 1-13.

Qian Zhang, Changpeng Hu, Jingbin Huang, Wuyi Liu, Wenjing Lai, Faning Leng, Qin Tang, Yali Liu, Qing Wang, Min Zhou, Fangfang Sheng, Guobing Li and Rong Zhang. "ROCK1 induces dopaminergic nerve cell apoptosis via the activation of Drp1-mediated aberrant mitochondrial fission in Parkinson’s disease" Experimental and Molecular Medicine 51(2019) : 1-13.

Qian Zhang; Changpeng Hu; Jingbin Huang; Wuyi Liu; Wenjing Lai; Faning Leng; Qin Tang; Yali Liu; Qing Wang; Min Zhou; Fangfang Sheng; Guobing Li; Rong Zhang. ROCK1 induces dopaminergic nerve cell apoptosis via the activation of Drp1-mediated aberrant mitochondrial fission in Parkinson’s disease. Experimental and Molecular Medicine, 51, 1-13.

Qian Zhang; Changpeng Hu; Jingbin Huang; Wuyi Liu; Wenjing Lai; Faning Leng; Qin Tang; Yali Liu; Qing Wang; Min Zhou; Fangfang Sheng; Guobing Li; Rong Zhang. ROCK1 induces dopaminergic nerve cell apoptosis via the activation of Drp1-mediated aberrant mitochondrial fission in Parkinson’s disease. Experimental and Molecular Medicine. 2019; 51 1-13.

Qian Zhang, Changpeng Hu, Jingbin Huang, Wuyi Liu, Wenjing Lai, Faning Leng, Qin Tang, Yali Liu, Qing Wang, Min Zhou, Fangfang Sheng, Guobing Li, Rong Zhang. ROCK1 induces dopaminergic nerve cell apoptosis via the activation of Drp1-mediated aberrant mitochondrial fission in Parkinson’s disease. 2019; 51 1-13.

Qian Zhang, Changpeng Hu, Jingbin Huang, Wuyi Liu, Wenjing Lai, Faning Leng, Qin Tang, Yali Liu, Qing Wang, Min Zhou, Fangfang Sheng, Guobing Li and Rong Zhang. "ROCK1 induces dopaminergic nerve cell apoptosis via the activation of Drp1-mediated aberrant mitochondrial fission in Parkinson’s disease" Experimental and Molecular Medicine 51(2019) : 1-13.