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This study investigated effects of mothers’ pre- and post-natal depression on infants’ communication competency development. Using the data of Panel Study on Korean Children(PSKC) collected from 2008 to 2010, 537 mothers who experienced prenatal depression and their infants were studied. Three research questions were suggested: 1) Are there differences in the levels of mothers’ depression at 1 month before delivery, 1 month after delivery, and 4 months after delivery? 2) Are there differences in the levels of infants’ communication competency development at 1 year, 2 years, and 3 years of age? 3) How are the longitudinal effects of mothers’ pre- and post-natal depression on infants’ communication competency development? To analyze data, repeated measurement ANOVA and structural equation modeling were used. Findings are as follows: 1) A U-shape was found in the process of mothers’ depression from 1 month before delivery to 4 months after delivery. 2) A U-shape was found from infants’ communication competency from 1 year to 3 years after birth. 3) Mothers’ depression at 1 month after delivery positively affected their depression at 4 months after delivery. 4) Infants’ communication competency development at 1 year after birth positively affected their communication competency development at 2 years after birth. 5) Mothers’ post-natal depression significantly affected infants’ communication competency development at 1 year and 2 years after birth. The current findings suggest that intervention programs for mothers’ post-natal depression at the beginning stage are required to improve child communication competency.