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Background and Objectives Various surgical approaches have been employed for the completeresection of inverted papilloma (IP) of the nose and paranasal sinus. Sacrificing the inferiorturbinate (IT) and nasolacrimal duct (NLD) is often unavoidable due to the anatomy of maxillarysinus. However, the prelacrimal recess approach (PLRA) provides a wider entrance to themaxillary sinus without the ablation of NLD and IT. We present seven cases of IP successfullytreated by the PLRA. Subjects and Method We collected data from seven different cases involving patients whounderwent resection of IP by means of the PLRA from 2016 to 2017. If the lesion could not be removedfirst via middle meatal antrostomy (MMA), then PLRA was attempted. The surgical specimenswere all confirmed to be IP. Results Preoperative imaging studies demonstrated that the lesions of IP were located mainlyin the maxillary sinus. All of the seven patients had unilateral lesions and all tumors were completelyresected via PLRA. The follow-up ranged from 3 to 24 months, during which no recurrenceor complications were observed in any of the seven patients. Conclusion PLRA provides an adequate operation field without unfavorable scars. It allowsthe preservation of sinus structure and function. PLRA is feasible and can be used for the diffusemaxillary sinus IP.