초록 열기/닫기 버튼
ObjectiveTo investigate the perinatal outcomes of twin pregnancies according to maternal age. MethodsThis is a retrospective cohort study of twin pregnancies delivered ≥24 weeks’ gestation at a tertiary academic hospitalfrom 1995 to 2016. Subjects were categorized into 5 groups according to maternal age: <25, 25–29, 30–34, 35–39, and≥40 years. Maternal and neonatal outcomes of each maternal age group were analyzed using the Jonckheere-Terpstratest and the linear-by-linear association test. ResultsA total of 1,936 twin pregnant women were included, of which 47 (2.4%), 470 (24.3%), 948 (49.0%), 417 (21.5%),and 54 (2.7%) women were aged <25, 25–29, 30–34, 35–39, and ≥40 years, respectively. Higher maternal age wassignificantly associated with a higher rate of dichorionic twins and a higher risk of gestational diabetes and placentaprevia. However, rates of preterm labor, preterm premature rupture of membranes, cervical incompetence, pretermdelivery, preeclampsia, placenta abruption, and cesarean section were not associated with maternal age. Birth weightincreased and the rate of admission to the neonatal intensive care unit (NICU) decreased with older maternal age,but other neonatal outcomes did not change with age. Maternal age was significantly associated with a lower rate ofNICU admission after controlling for potential confounding factors in multivariable analysis. ConclusionAdvanced maternal age in twin pregnancies was associated with increased risk of gestational diabetes, placentaprevia, and higher birth weight but a lower rate of NICU admission. However, other outcomes were not significantlyassociated with maternal age.
