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Purpose: Coronary artery diseases (CADs) are the leading causes of death in the world. Recent studies have reported that differentiallyexpressed microRNAs (miRNAs) are associated with prognosis or major adverse cardiac events (MACEs) in CAD patients. In a previous meta-analysis, the authors made serious mistakes that we aimed to correct through an updated systematic reviewand meta-analysis of the prognostic value of altered miRNAs in patients with CADs. Materials and Methods: We performed a systematic search of MEDLINE (from inception to May 2017) and EMBASE (from inceptionto May 2017) for English-language publications. Studies of CADs with results on miRNAs that reported survival data orMACEs were included. Data were extracted from each publication independently by two reviewers. Results: After reviewing 515 articles, a total eight studies were included in this study. We measured pooled hazard ratios (HRs)and 95% confidence intervals (CIs) of miRNA 133a with a fixed-effect model (pooled HR, 2.35; 95% CI, 1.56–3.55). High expressionof miRNA 133a, 208b, 126, 197, 223, and 122-5p were associated with high mortality. Additionally, high levels of miRNA 208b,499-5p, 134, 328, and 34a were related with MACEs. Conclusion: The present study confirmed that miRNA 133a, which was associated with high mortality in CAD patients, holdsprognostic value in CAD. More importantly, this study corrected issues raised against a prior meta-analysis and provides accurateinformation.
