@article{ART002375875,
author={Lingfeng He and Hong Zhu and Shiying Zhou and Ting Wu and Huan Wu and Huan Yang and Huiwen Mao and Chandra SekharKathera and Avilala Janardhan and Ashlin M. Edick and Anna Zhang and Zhigang Hu and Feiyan Pan and Zhigang Guo},
title={Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells},
journal={Experimental and Molecular Medicine},
issn={1226-3613},
year={2018},
volume={50},
pages={1-12}
}

TY - JOUR
AU - Lingfeng He
AU - Hong Zhu
AU - Shiying Zhou
AU - Ting Wu
AU - Huan Wu
AU - Huan Yang
AU - Huiwen Mao
AU - Chandra SekharKathera
AU - Avilala Janardhan
AU - Ashlin M. Edick
AU - Anna Zhang
AU - Zhigang Hu
AU - Feiyan Pan
AU - Zhigang Guo
TI - Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells
T2 - Experimental and Molecular Medicine
JO - Experimental and Molecular Medicine
PY - 2018
VL - 50
IS - null
PB - 생화학분자생물학회
SP - 1
EP - 12
SN - 1226-3613
AB - Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. 5-Fluorouracil (5-FU) is widely used in the treatment of cancers, but its antineoplastic activity is limited in drug-resistant cancer cells. To investigate the detailed mechanism of 5-FU resistance, we developed a model of 5-FU-resistant cells from HCT-8 cells, a wellestablished colorectal cancer cell line. We found that the drug-resistant cells demonstrated high expression of TCF4 and β-catenin, indicating an upregulated Wnt pathway. A microarray analysis revealed that the suppression of the checkpoint kinase 1 (CHK1) pathway explained the resistance to 5-FU, especially in p53 wild-type cancer cells such as HCT-8. Our data also demonstrated that the CHK1 pathway is suppressed by the Wnt pathway in 5-FU-resistant cells. In summary, we have discovered a novel mechanism for 5-FU resistance mediated by histone deacetylation, which also revealed the crosstalk between the Wnt pathway and CHK1 pathway.
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Lingfeng He, Hong Zhu, Shiying Zhou, Ting Wu, Huan Wu, Huan Yang, Huiwen Mao, Chandra SekharKathera, Avilala Janardhan, Ashlin M. Edick, Anna Zhang, Zhigang Hu, Feiyan Pan and Zhigang Guo. 2018, "Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells", Experimental and Molecular Medicine, vol.50, pp.1-12.

Lingfeng He, Hong Zhu, Shiying Zhou, Ting Wu, Huan Wu, Huan Yang, Huiwen Mao, Chandra SekharKathera, Avilala Janardhan, Ashlin M. Edick, Anna Zhang, Zhigang Hu, Feiyan Pan, Zhigang Guo "Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells" Experimental and Molecular Medicine 50 pp.1-12 (2018) : 1.

Lingfeng He, Hong Zhu, Shiying Zhou, Ting Wu, Huan Wu, Huan Yang, Huiwen Mao, Chandra SekharKathera, Avilala Janardhan, Ashlin M. Edick, Anna Zhang, Zhigang Hu, Feiyan Pan, Zhigang Guo. Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells. 2018; 50 1-12.

Lingfeng He, Hong Zhu, Shiying Zhou, Ting Wu, Huan Wu, Huan Yang, Huiwen Mao, Chandra SekharKathera, Avilala Janardhan, Ashlin M. Edick, Anna Zhang, Zhigang Hu, Feiyan Pan and Zhigang Guo. "Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells" Experimental and Molecular Medicine 50(2018) : 1-12.

Lingfeng He; Hong Zhu; Shiying Zhou; Ting Wu; Huan Wu; Huan Yang; Huiwen Mao; Chandra SekharKathera; Avilala Janardhan; Ashlin M. Edick; Anna Zhang; Zhigang Hu; Feiyan Pan; Zhigang Guo. Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells. Experimental and Molecular Medicine, 50, 1-12.

Lingfeng He; Hong Zhu; Shiying Zhou; Ting Wu; Huan Wu; Huan Yang; Huiwen Mao; Chandra SekharKathera; Avilala Janardhan; Ashlin M. Edick; Anna Zhang; Zhigang Hu; Feiyan Pan; Zhigang Guo. Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells. Experimental and Molecular Medicine. 2018; 50 1-12.

Lingfeng He, Hong Zhu, Shiying Zhou, Ting Wu, Huan Wu, Huan Yang, Huiwen Mao, Chandra SekharKathera, Avilala Janardhan, Ashlin M. Edick, Anna Zhang, Zhigang Hu, Feiyan Pan, Zhigang Guo. Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells. 2018; 50 1-12.

Lingfeng He, Hong Zhu, Shiying Zhou, Ting Wu, Huan Wu, Huan Yang, Huiwen Mao, Chandra SekharKathera, Avilala Janardhan, Ashlin M. Edick, Anna Zhang, Zhigang Hu, Feiyan Pan and Zhigang Guo. "Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells" Experimental and Molecular Medicine 50(2018) : 1-12.