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Purpose: The present study investigated the dynamics and prognostic role of messenger RNA (mRNA) expression responsible for18F-fluorodeoxyglucose (FDG) uptake in FDG positron emission tomography (PET) and radioactive iodine (131I) uptake in wholebodyradioactive iodine scans (WBS) in papillary thyroid cancer (PTC) patients. Materials and Methods: The primary and processed data were downloaded from the Genomic Data Commons Data Portal. Expressiondata for sodium/iodide symporter (solute carrier family 5 member 5, SLC5A5), hexokinase (HK1–3), glucose-6-phosphatedehydrogenase (G6PD), and glucose transporter (solute carrier family 2, SLC2A1–4) mRNA were collected. Results: Expression of SLC5A5 mRNA were negatively correlated with SLC2A1 mRNA and positively correlated with SLC2A4mRNA. In PTC with BRAF mutations, expressions of SLC2A1, SLC2A3, HK2, and HK3 mRNA were higher than those in PTC withoutBRAF mutations. Expression of SLC5A5, SLC2A4, HK1, and G6PD mRNA was lower in PTC without BRAF mutation. PTCswith higher expression of SLC5A5 mRNA had more favorable disease-free survival, but no association with overall survival. Conclusion: Expression of SLC5A5 mRNA was negatively correlated with SLC2A1 mRNA. This finding provides a molecular basisfor the management of PTC with negative WBS using 18F-FDG PET scans. In addition, higher expression of SLC5A5 mRNA wasassociated with less PTC recurrence, but not with deaths.
