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Background and Objectives:The present study was undertaken to determine and to compare the characteristics of bone wax, fibrofatty tisues or bone graft materials (Lubboc)Materials and Method:The guinea pigs were used to perform obliteration of the dorsal bullae of the temporal bone using bone wax, fibrofatty tisues or Lubboc. Twelve weeks after transplantation, the animals were sacrificed, and histological sections were prepared. Histological evaluations were performed to determine changes of the dorsal bulae mucosa of the temporal bone and the implanted materials. Results:reactions within the dorsal bullae mucosa of the temporal bone. A large amount of absorption was observed in the fibrofatty tissue. On the other hand, in the case using Luboc, real bonds between the new bone and native bone were observed, as wel as a ma-ture trabecular bone traversing throughout the entire implant materials. Bone formation as induced by the Lubocimplantation appeared to be a physiological reaction, which was further supported by observation of extensive neovascularization within the Conclusion:Based on our curent observations, we consider Lubbocas a superior implant material for bone wax and fibrofatty tisues.