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Low-grade nasopharyngeal papillary adenocarcinoma is a very rare nasopharyngeal, surface epithelium-derived malignant tumor characterized with adenocarcinomatous differentiation and an indolent biological behavior. We report a case of 36-year old female presenting a papillary adenocarcinoma of the nasopharynx. The tumor was of a 0.5 cm sized exophytic mass located on the nasopharyngeal mucosa near the posterior choanal septum. Because of the histologic similarities with thyroid papillary carcinoma, it was necessary to rule out metastasis from thyroid by immunohistochemical staining for thyroglobulin. Surgical excisionwas done via transpalatal approach;mass was removed with a clear resection margin.