초록 열기/닫기 버튼
Background and Objectives：Protease-activated receptor 2 (PAR-2) has been known to play an important role in modulatinghomeostasis and inflammation in the airways. But only a little is known about the localization of PAR-2 in nasal mucosa andrelationship between PAR-2 and nasal mucosal inflammation. In this study, we investigated the localization of PAR-2 in nasalpolyp and turbinate mucosa and examined the relationship between the PAR-2 expression and eosinophil infiltration. Materialsand Method：Nasal polyp tissues were obtained from 20 nasal polyposis patients and inferior turbinate tissues were taken from12 nasal septal deviation patients as control. PAR-2 expression was assessed by immunohistochemical staining. We comparedPAR-2 immunoreactivity between nasal polyp and turbinate mucosa. Infiltrated eosinophils were counted ands its correlationwith the intensity of PAR-2 immunoreactivity in nasal polyp was determined. Also, we evaluated the PAR-2 expression in thepresence of allergic rhinitis. Results：PAR-2 immunoreactivity was detected in the nasal mucosal epithelium, endothelial cells,vascular myocytes, submucosal glands, fibroblasts and inflammatory cells. PAR-2 expression was similar between nasal polypand turbinate mucosa, but inflammatory cells of nasal polyp showed stronger immunoreactivity than those of turbinate. Immunoreactivityin inflammatory cells showed correlation with eosinophil infiltration in nasal polyp. There were no differences inthe PAR-2 expression between allergic rhinitis patients and non-allergic rhinitis patients. Conclusion：Increased expression ofPAR-2 in inflammatory cells of nasal polyp and its correlation with eosinophil infiltration raise the possibility that PAR-2 mayplay a role in pathophysiology of nasal polyposis.
키워드열기/닫기 버튼
Nasal polypsEosinophilsPAR-2.
