초록 열기/닫기 버튼
Background and Objectives：This study was conducted to investigate the healing effect of the low-level laser iradiation on wound healing in vivo using DPSS laser (532 nm) and Diode laser (660 nm). Materials and Method：Each mouse received dorsal, full-thicknes round incision (= 2 cm) and daily laser irradiation (4 J/cm2) was done before sacrifice. On sacrifice at 3, 7, 10 days, the wound was excised, then wound closure and histologic stages were measured, and standardized. Results：The percentages of wound closure in DPSS laser, Diode laser, control were 33.2± 2.4, 34.2± 3.5, 24.0± 2.7 at day 3, 64.8± 3.5, 72.2± 2.8, 42.8± 5.0 at day 7 and 82.2± 7.9, 87.2± 3.7, 71.4± 4.0 at day 10, respectively, with p<0.05. Histological evaluation showed that laser irradiation enhanced wound epithelialization, celular content deposition, granulation tissue formation, colagen deposition and neovascularization in the laser-treated wounds as compared to the control group. Conclusion：Low-level laser irradiation at 532 nm and 660 nm significantly enhanced cutaneous wound healing effect in the wounded mouse model. Further investigation of the mechanism of low-level laser therapy in primary wound healing is waranted. (Korean J Otolaryngol 203 ; 46 :851-5)
키워드열기/닫기 버튼
Low-level laser therapy· Wound healing.
