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Although invasive fungal infections of the paranasal sinuses have been well described in immunocompromised patients, those affecting the ear and temporal bone are uncommon. For these diseases, early suspicion and proving the invasiveness of the fungus with biopsy are very important. Systemic antifungal treatment and wide surgical debridement are the treatment of choice. However, a latent infection is always at risk during the long-term medical therapy. We report, with a literature review, a case of brain abscess from invasive fungal otitis media in an immunocompromised patient who has shown improvement with earlier antifungal medication and surgical debridement. Korean J Otorhinolaryngol-Head Neck Surg 2014;57(7):484-8