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The nasopalatine duct cyst is the most common cyst of nonodontogenic origin in the maxilla. It occurs approximately 1% of the population. Currently, it’s origin is thought to be from oronasal ducts within the incisive canal, however it is still a source of controversy. The etiology still remains unknown. Possible causes include trauma, infection, spontaneous proliferation. Symptoms were reported include swelling, drainage and pain. Radiographically, nasopalatine duct cyst usually appear as a round , ovoid or heart shaped radiolucent mass in the anterior palate. Surgical enucleation is the recommended treatment. However, if the size of cystic is above 2 cm and there is a risk of oroantral fistula after enucleation, marsupialization is indicated. The authors report a case of a large nasopalatine duct cyst which is treated with endoscopic marsupialization.