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Purpose: The purpose of this study was to investigate relationships among anger, depression, and self-esteem in female college students. Methods: First-semester nursing students (N=248) completed surveys to estimate correlations of anger, depression, and self-esteem. Participants were recruited from two colleges in S and G cities,Korea. Data were collected from April 10 to 30, 2011. Measurement tools were for anger, Novaco Anger Scale (NAS), for depression, Beck Depression Inventory (BDI), and for self-esteem, Rosenberg Self-esteem Scale. SPSS/WIN 17.0 version was used for descriptive analysis, t-test, one-way ANOVA, Pearson correlation, and multiple regression. Results: There were significant differences in self-esteem according to mood of family. Anger was significantly correlated with depression and self-esteem, which were significant predictors (30.0%) of anger. Conclusion: These results indicate that health promotion programs conducted by nurses for college student health care should target depression while bolstering self-esteem to promote anger management.