@article{ART001099915,
author={장정원 and 최시호 and 차미주 and 김남율 and 황순정 and 이종호},
title={Serotonin transporter mRNA expression in the dorsal raphe nucleus of a tumor bearing mouse},
journal={Experimental and Molecular Medicine},
issn={1226-3613},
year={2005},
volume={37},
number={1},
pages={65-69}
}

TY - JOUR
AU - 장정원
AU - 최시호
AU - 차미주
AU - 김남율
AU - 황순정
AU - 이종호
TI - Serotonin transporter mRNA expression in the dorsal raphe nucleus of a tumor bearing mouse
T2 - Experimental and Molecular Medicine
JO - Experimental and Molecular Medicine
PY - 2005
VL - 37
IS - 1
PB - 생화학분자생물학회
SP - 65
EP - 69
SN - 1226-3613
AB - This study was conducted to determine if an oral squamous cel carcinoma alters mRNA ex-presion of serotonin transporter (5-HTT) in the central nervous system. KB cell line derived from a human oral squamous cell carcinoma was inoculated into nude mice, and mRNA expres-sion level of 5-HT in the dorsal raphe nucleus in situ hybridization when the tumor mass reached to -10% of total body weight. Plasma leptin levels were determin-ed by radioimunoassay method using a com-mercial kit. 5-HTT mRNA level was significantly decreased in the DRN of tumor bearing mice, compared to the age-matching non-tumor con-trol. Plasma leptin level decreased concomitantly in tumor bearing mice. These results sugest that oral carcinoma may supress 5-HT gene expres-sion in the central nervous system, perhaps in relation with decreased plasma leptin level.
KW - depression; gene expression; in situ hy-bridization; leptin; serotonin; tumor
DO -
UR -
ER -

장정원, 최시호, 차미주, 김남율, 황순정 and 이종호. 2005, "Serotonin transporter mRNA expression in the dorsal raphe nucleus of a tumor bearing mouse", Experimental and Molecular Medicine, vol.37, no.1 pp.65-69.

장정원, 최시호, 차미주, 김남율, 황순정, 이종호 "Serotonin transporter mRNA expression in the dorsal raphe nucleus of a tumor bearing mouse" Experimental and Molecular Medicine 37.1 pp.65-69 (2005) : 65.

장정원, 최시호, 차미주, 김남율, 황순정, 이종호. Serotonin transporter mRNA expression in the dorsal raphe nucleus of a tumor bearing mouse. 2005; 37(1), 65-69.

장정원, 최시호, 차미주, 김남율, 황순정 and 이종호. "Serotonin transporter mRNA expression in the dorsal raphe nucleus of a tumor bearing mouse" Experimental and Molecular Medicine 37, no.1 (2005) : 65-69.

장정원; 최시호; 차미주; 김남율; 황순정; 이종호. Serotonin transporter mRNA expression in the dorsal raphe nucleus of a tumor bearing mouse. Experimental and Molecular Medicine, 37(1), 65-69.

장정원; 최시호; 차미주; 김남율; 황순정; 이종호. Serotonin transporter mRNA expression in the dorsal raphe nucleus of a tumor bearing mouse. Experimental and Molecular Medicine. 2005; 37(1) 65-69.

장정원, 최시호, 차미주, 김남율, 황순정, 이종호. Serotonin transporter mRNA expression in the dorsal raphe nucleus of a tumor bearing mouse. 2005; 37(1), 65-69.

장정원, 최시호, 차미주, 김남율, 황순정 and 이종호. "Serotonin transporter mRNA expression in the dorsal raphe nucleus of a tumor bearing mouse" Experimental and Molecular Medicine 37, no.1 (2005) : 65-69.