@article{ART001100396,
author={최영기 and 김태경 and 김철중 and 이중섭 and 오세영 and 주한수 and Douglas N. Foster and 홍기창 and 유승권 and 김형기},
title={Activation of the intrinsic mitochondrial apoptotic pathway in swine influenza virus-mediated cell death},
journal={Experimental and Molecular Medicine},
issn={1226-3613},
year={2006},
volume={38},
number={1},
pages={11-17}
}

TY - JOUR
AU - 최영기
AU - 김태경
AU - 김철중
AU - 이중섭
AU - 오세영
AU - 주한수
AU - Douglas N. Foster
AU - 홍기창
AU - 유승권
AU - 김형기
TI - Activation of the intrinsic mitochondrial apoptotic pathway in swine influenza virus-mediated cell death
T2 - Experimental and Molecular Medicine
JO - Experimental and Molecular Medicine
PY - 2006
VL - 38
IS - 1
PB - 생화학분자생물학회
SP - 11
EP - 17
SN - 1226-3613
AB - The mitochondrial pathway of swine influenza virus (SIV)-induced apoptosis was investigated using porcine kidney (PK-15) cells, swine testicle (ST) cells, and HeLa cervical carcinoma cells which are known not to support viral replication. As judged by cell tation, PK-15 and ST cells infected with three different subtypes of SIV (H1N1, H3N2, and H1N2) were obviously killed by apoptosis, not necrosis. SIV infection in PK-15 and HeLa cells was shown to decrease the cellular levels of Bcl-2 protein com-pared to that of mock-infected control cells at 24 h post-infection, whereas expression levels of Bax protein increased in the PK-15 cells, but did not increase in HeLa cells by SIV infection. Cytochrome c upregulation was also observed in cytosolic frac-tions of the PK-15 and HeLa cells infected with SIV. Apoptosome (a multi-protein complex consisting of cytochrome c, Apaf-1, caspase-9, and ATP) forma-tion was confirmed by immunoprecipitation using cytochrome c antibody. Furthermore, SIV infection increased the cellular levels of TAJ, an activator of the JNK- stressing pathway, and the c-Jun protein in the PK-15 and HeLa cells. Taken together, these results suggest that the mitochondrial pathway should be implicated in the apoptosis of PK-15 cells induced by SIV infection.
KW - apoptosis; cytochrome c; influenza virus; mitochondria; proto-oncogene proteins c-Bcl-2; pro-to-oncogene proteins c-jun
DO -
UR -
ER -

최영기, 김태경, 김철중, 이중섭, 오세영, 주한수, Douglas N. Foster, 홍기창, 유승권 and 김형기. 2006, "Activation of the intrinsic mitochondrial apoptotic pathway in swine influenza virus-mediated cell death", Experimental and Molecular Medicine, vol.38, no.1 pp.11-17.

최영기, 김태경, 김철중, 이중섭, 오세영, 주한수, Douglas N. Foster, 홍기창, 유승권, 김형기 "Activation of the intrinsic mitochondrial apoptotic pathway in swine influenza virus-mediated cell death" Experimental and Molecular Medicine 38.1 pp.11-17 (2006) : 11.

최영기, 김태경, 김철중, 이중섭, 오세영, 주한수, Douglas N. Foster, 홍기창, 유승권, 김형기. Activation of the intrinsic mitochondrial apoptotic pathway in swine influenza virus-mediated cell death. 2006; 38(1), 11-17.

최영기, 김태경, 김철중, 이중섭, 오세영, 주한수, Douglas N. Foster, 홍기창, 유승권 and 김형기. "Activation of the intrinsic mitochondrial apoptotic pathway in swine influenza virus-mediated cell death" Experimental and Molecular Medicine 38, no.1 (2006) : 11-17.

최영기; 김태경; 김철중; 이중섭; 오세영; 주한수; Douglas N. Foster; 홍기창; 유승권; 김형기. Activation of the intrinsic mitochondrial apoptotic pathway in swine influenza virus-mediated cell death. Experimental and Molecular Medicine, 38(1), 11-17.

최영기; 김태경; 김철중; 이중섭; 오세영; 주한수; Douglas N. Foster; 홍기창; 유승권; 김형기. Activation of the intrinsic mitochondrial apoptotic pathway in swine influenza virus-mediated cell death. Experimental and Molecular Medicine. 2006; 38(1) 11-17.

최영기, 김태경, 김철중, 이중섭, 오세영, 주한수, Douglas N. Foster, 홍기창, 유승권, 김형기. Activation of the intrinsic mitochondrial apoptotic pathway in swine influenza virus-mediated cell death. 2006; 38(1), 11-17.

최영기, 김태경, 김철중, 이중섭, 오세영, 주한수, Douglas N. Foster, 홍기창, 유승권 and 김형기. "Activation of the intrinsic mitochondrial apoptotic pathway in swine influenza virus-mediated cell death" Experimental and Molecular Medicine 38, no.1 (2006) : 11-17.