@article{ART001099880,
author={안봉현 and 민규식 and 배외식 and 배영석 and 민도식},
title={Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells},
journal={Experimental and Molecular Medicine},
issn={1226-3613},
year={2006},
volume={38},
number={1},
pages={55-62}
}

TY - JOUR
AU - 안봉현
AU - 민규식
AU - 배외식
AU - 배영석
AU - 민도식
TI - Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells
T2 - Experimental and Molecular Medicine
JO - Experimental and Molecular Medicine
PY - 2006
VL - 38
IS - 1
PB - 생화학분자생물학회
SP - 55
EP - 62
SN - 1226-3613
AB - Elevated expression of protein casein kinase II (CKII) stimulated basal phospholipase D (PLD) activity as well as PMA-induced PLD activation in human U87 astroglioma cells. Moreover, CKII-selective inhibi-tor, emodin and apigenin suppressed PMA-induced PLD activation in a dose-dependent manner as well as basal PLD activity, suggesting the involvement of CKII in the activation of both PLD1 and PLD2. CKII was associated with PLD1 and PLD2 in co-transfection experiments. Furthermore, CKII induced serine/thre -onine phosphorylation of PLD2 in vivo, and the multiple regions of PLD2 were phosphorylated by CKII in vitro kinase assay using glutathione S-trans -ferase- PLD2 fusion protein fragments. Elevated expression of CKII or PLD increased cell proliferation but pretreatment of cells with 1-butanol suppressed CKII-induced cell proliferation. These results sug -gest that CKII is involved in proliferation of U87 cells at least in part, through stimulation of PLD activity.
KW - casin kinase II; cell proliferation; phos-pholipase D; phosphorylation
DO -
UR -
ER -

안봉현, 민규식, 배외식, 배영석 and 민도식. 2006, "Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells", Experimental and Molecular Medicine, vol.38, no.1 pp.55-62.

안봉현, 민규식, 배외식, 배영석, 민도식 "Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells" Experimental and Molecular Medicine 38.1 pp.55-62 (2006) : 55.

안봉현, 민규식, 배외식, 배영석, 민도식. Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells. 2006; 38(1), 55-62.

안봉현, 민규식, 배외식, 배영석 and 민도식. "Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells" Experimental and Molecular Medicine 38, no.1 (2006) : 55-62.

안봉현; 민규식; 배외식; 배영석; 민도식. Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells. Experimental and Molecular Medicine, 38(1), 55-62.

안봉현; 민규식; 배외식; 배영석; 민도식. Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells. Experimental and Molecular Medicine. 2006; 38(1) 55-62.

안봉현, 민규식, 배외식, 배영석, 민도식. Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells. 2006; 38(1), 55-62.

안봉현, 민규식, 배외식, 배영석 and 민도식. "Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells" Experimental and Molecular Medicine 38, no.1 (2006) : 55-62.