@article{ART001099839,
author={이금주 and 김성진 and 김석원 and 최송현 and 신유찬 and 박상하 and 문보현 and 조의진 and 이민수 and 최상현 and 전보권 and 신경호},
title={Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus},
journal={Experimental and Molecular Medicine},
issn={1226-3613},
year={2006},
volume={38},
number={1},
pages={44-54}
}

TY - JOUR
AU - 이금주
AU - 김성진
AU - 김석원
AU - 최송현
AU - 신유찬
AU - 박상하
AU - 문보현
AU - 조의진
AU - 이민수
AU - 최상현
AU - 전보권
AU - 신경호
TI - Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus
T2 - Experimental and Molecular Medicine
JO - Experimental and Molecular Medicine
PY - 2006
VL - 38
IS - 1
PB - 생화학분자생물학회
SP - 44
EP - 54
SN - 1226-3613
AB - New-born cells continue to proliferate and survive to become mature granule cells in adult rat hippo-campus. Although this process, known as neuro-whether chronic stress affects neurogenesis. To de-termine whether chronic mild stress (CMS) influ-ences neurogenesis in the adult rat hippocampus, male Sprague-Dawley rats were exposed to CMS and administered bromodeoxyuridine (BrdU) before or after CMS to observe the survival/differentiation or proliferation of new-born cells, respectively. In addition, we measured brain-derived neurotrophic factor (BDNF) mRNA in the granule cell layer (GCL) of the hippocampus, because BDNF is known to play an important role in the survival of new-born cells. CMS significantly decreased the survival of new- born cells in the GCL, but did not influence the proliferation or differentiation of new-born cells. CMS did not affect the proliferation and survival of new-born cells in the hilus. In addition, CMS did not change BDNF mRNA levels in the GCL. These results demonstrate that CMS reduces the survival of suggesting that repeated mild stress could influence a part of neurogenesis, but not the whole part of neurogenesis. These results raise the possibility that the survival of new-born cells may be suppressed in the presence of normal BDNF mRNA levels in GCL.
KW - brain-derived neurotrophic factor; bro-modeoxyuridine; depression; hippocampus; neuro-genesis; stress
DO -
UR -
ER -

이금주, 김성진, 김석원, 최송현, 신유찬, 박상하, 문보현, 조의진, 이민수, 최상현, 전보권 and 신경호. 2006, "Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus", Experimental and Molecular Medicine, vol.38, no.1 pp.44-54.

이금주, 김성진, 김석원, 최송현, 신유찬, 박상하, 문보현, 조의진, 이민수, 최상현, 전보권, 신경호 "Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus" Experimental and Molecular Medicine 38.1 pp.44-54 (2006) : 44.

이금주, 김성진, 김석원, 최송현, 신유찬, 박상하, 문보현, 조의진, 이민수, 최상현, 전보권, 신경호. Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus. 2006; 38(1), 44-54.

이금주, 김성진, 김석원, 최송현, 신유찬, 박상하, 문보현, 조의진, 이민수, 최상현, 전보권 and 신경호. "Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus" Experimental and Molecular Medicine 38, no.1 (2006) : 44-54.

이금주; 김성진; 김석원; 최송현; 신유찬; 박상하; 문보현; 조의진; 이민수; 최상현; 전보권; 신경호. Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus. Experimental and Molecular Medicine, 38(1), 44-54.

이금주; 김성진; 김석원; 최송현; 신유찬; 박상하; 문보현; 조의진; 이민수; 최상현; 전보권; 신경호. Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus. Experimental and Molecular Medicine. 2006; 38(1) 44-54.

이금주, 김성진, 김석원, 최송현, 신유찬, 박상하, 문보현, 조의진, 이민수, 최상현, 전보권, 신경호. Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus. 2006; 38(1), 44-54.

이금주, 김성진, 김석원, 최송현, 신유찬, 박상하, 문보현, 조의진, 이민수, 최상현, 전보권 and 신경호. "Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus" Experimental and Molecular Medicine 38, no.1 (2006) : 44-54.