@article{ART001100358,
author={진철 and 배재호 and 김미주 and 황지영 and 김수진 and 윤만수 and 이민기 and 김동완 and 정병선 and 강치덕 and 김선희},
title={Radiosensitization by targeting radioresistance-related genes with protein kinase A inhibitor in radioresistant cancer cells},
journal={Experimental and Molecular Medicine},
issn={1226-3613},
year={2005},
volume={37},
number={6},
pages={608-618}
}

TY - JOUR
AU - 진철
AU - 배재호
AU - 김미주
AU - 황지영
AU - 김수진
AU - 윤만수
AU - 이민기
AU - 김동완
AU - 정병선
AU - 강치덕
AU - 김선희
TI - Radiosensitization by targeting radioresistance-related genes with protein kinase A inhibitor in radioresistant cancer cells
T2 - Experimental and Molecular Medicine
JO - Experimental and Molecular Medicine
PY - 2005
VL - 37
IS - 6
PB - 생화학분자생물학회
SP - 608
EP - 618
SN - 1226-3613
AB - Here we determined which radiation-responsive genes were altered in radioresistant CEM/IR and FM3A/IR variants, which showed higher resistance to irradiation than parental human leukemia CEM and mouse mammary carcinoma FM3A cells, respec-tively and studied if radioresistance observed after radiotherapy could be restored by inhibition of protein kinase A. The expressions of DNA-PKcs, Ku70/80, Rad51 and Rad54 genes that related to DNA damage repair, and Bcl-2 and NF-κB genes that related to antiapoptosis, were up-regulated, but the regulated in the radioresistant cells as compared to each parental counterpart. We also revealed that the combined treatment of radiation and the inhibitor of protein kinase A (PKA) to these radioresistant cells resulted in synergistic inhibition of DNA-PK, Rad51 and Bcl-2 expressions of the cells, and conse-quently restored radiosensitivity of the cells. Our results propose that combined treatment with radiotherapy and PKA inhibitor can be a novel therapeutic strategy to radioresistant cancers.
KW - cyclic AMP-dependent protein kinases; gene expression profiling; gene expression regulation, neoplastic; radiation
DO -
UR -
ER -

진철, 배재호, 김미주, 황지영, 김수진, 윤만수, 이민기, 김동완, 정병선, 강치덕 and 김선희. 2005, "Radiosensitization by targeting radioresistance-related genes with protein kinase A inhibitor in radioresistant cancer cells", Experimental and Molecular Medicine, vol.37, no.6 pp.608-618.

진철, 배재호, 김미주, 황지영, 김수진, 윤만수, 이민기, 김동완, 정병선, 강치덕, 김선희 "Radiosensitization by targeting radioresistance-related genes with protein kinase A inhibitor in radioresistant cancer cells" Experimental and Molecular Medicine 37.6 pp.608-618 (2005) : 608.

진철, 배재호, 김미주, 황지영, 김수진, 윤만수, 이민기, 김동완, 정병선, 강치덕, 김선희. Radiosensitization by targeting radioresistance-related genes with protein kinase A inhibitor in radioresistant cancer cells. 2005; 37(6), 608-618.

진철, 배재호, 김미주, 황지영, 김수진, 윤만수, 이민기, 김동완, 정병선, 강치덕 and 김선희. "Radiosensitization by targeting radioresistance-related genes with protein kinase A inhibitor in radioresistant cancer cells" Experimental and Molecular Medicine 37, no.6 (2005) : 608-618.

진철; 배재호; 김미주; 황지영; 김수진; 윤만수; 이민기; 김동완; 정병선; 강치덕; 김선희. Radiosensitization by targeting radioresistance-related genes with protein kinase A inhibitor in radioresistant cancer cells. Experimental and Molecular Medicine, 37(6), 608-618.

진철; 배재호; 김미주; 황지영; 김수진; 윤만수; 이민기; 김동완; 정병선; 강치덕; 김선희. Radiosensitization by targeting radioresistance-related genes with protein kinase A inhibitor in radioresistant cancer cells. Experimental and Molecular Medicine. 2005; 37(6) 608-618.

진철, 배재호, 김미주, 황지영, 김수진, 윤만수, 이민기, 김동완, 정병선, 강치덕, 김선희. Radiosensitization by targeting radioresistance-related genes with protein kinase A inhibitor in radioresistant cancer cells. 2005; 37(6), 608-618.

진철, 배재호, 김미주, 황지영, 김수진, 윤만수, 이민기, 김동완, 정병선, 강치덕 and 김선희. "Radiosensitization by targeting radioresistance-related genes with protein kinase A inhibitor in radioresistant cancer cells" Experimental and Molecular Medicine 37, no.6 (2005) : 608-618.