@article{ART000860137,
author={신순영 and 윤세창 and 김영호 and 김용식 and 이영한},
title={Phosphorylation of glycogen synthase kinase-3β at serine-9 by phospholipase Cγ1 through protein kinase C in rat 3Y1 fibroblasts},
journal={Experimental and Molecular Medicine},
issn={1226-3613},
year={2002},
volume={34},
number={6},
pages={444-450}
}

TY - JOUR
AU - 신순영
AU - 윤세창
AU - 김영호
AU - 김용식
AU - 이영한
TI - Phosphorylation of glycogen synthase kinase-3β at serine-9 by phospholipase Cγ1 through protein kinase C in rat 3Y1 fibroblasts
T2 - Experimental and Molecular Medicine
JO - Experimental and Molecular Medicine
PY - 2002
VL - 34
IS - 6
PB - 생화학분자생물학회
SP - 444
EP - 450
SN - 1226-3613
AB - Phospholipase Cγ1 (PLCγ1) plays an important role in controlling cellular proliferation and differ-entiation. PLCγ1 is overexpressed in some tu-mors, and its overexpresion induces solid tumors nisms underlying PLCγ1-induced cell proliferation are not fuly understood. Here we show that over-expression of PLCγ1 highly phosphorylated glyco-gen synthase kinase-3β (GSK-3β) at serine-9 in 3Y1 fibroblasts. Inhibition of protein kinase C (PKC)s with GF109203X abrogated GSK-3β phosphoryla-tion by PLCγ1. We also found that steady-state level of cyclin D1 protein, but not cyclin D1 mRNA, was highly elevated in response to serum stimu-lation in PLCγvector-transfected cels. Since GSK-3β is involved in cyclin D1 proteolysis in response to mitogenic stimulation, PLCγ1-mediated GSK-3β phosphoryla-tion may function as a regulation of cyclin D1 accumulation in PLCγ1-overexpressing cels.
KW - cyclin D1, fibroblasts, glycogen synthase kinase 3, phospholipase C, protein kinase C
DO -
UR -
ER -

신순영, 윤세창, 김영호, 김용식 and 이영한. 2002, "Phosphorylation of glycogen synthase kinase-3β at serine-9 by phospholipase Cγ1 through protein kinase C in rat 3Y1 fibroblasts", Experimental and Molecular Medicine, vol.34, no.6 pp.444-450.

신순영, 윤세창, 김영호, 김용식, 이영한 "Phosphorylation of glycogen synthase kinase-3β at serine-9 by phospholipase Cγ1 through protein kinase C in rat 3Y1 fibroblasts" Experimental and Molecular Medicine 34.6 pp.444-450 (2002) : 444.

신순영, 윤세창, 김영호, 김용식, 이영한. Phosphorylation of glycogen synthase kinase-3β at serine-9 by phospholipase Cγ1 through protein kinase C in rat 3Y1 fibroblasts. 2002; 34(6), 444-450.

신순영, 윤세창, 김영호, 김용식 and 이영한. "Phosphorylation of glycogen synthase kinase-3β at serine-9 by phospholipase Cγ1 through protein kinase C in rat 3Y1 fibroblasts" Experimental and Molecular Medicine 34, no.6 (2002) : 444-450.

신순영; 윤세창; 김영호; 김용식; 이영한. Phosphorylation of glycogen synthase kinase-3β at serine-9 by phospholipase Cγ1 through protein kinase C in rat 3Y1 fibroblasts. Experimental and Molecular Medicine, 34(6), 444-450.

신순영; 윤세창; 김영호; 김용식; 이영한. Phosphorylation of glycogen synthase kinase-3β at serine-9 by phospholipase Cγ1 through protein kinase C in rat 3Y1 fibroblasts. Experimental and Molecular Medicine. 2002; 34(6) 444-450.

신순영, 윤세창, 김영호, 김용식, 이영한. Phosphorylation of glycogen synthase kinase-3β at serine-9 by phospholipase Cγ1 through protein kinase C in rat 3Y1 fibroblasts. 2002; 34(6), 444-450.

신순영, 윤세창, 김영호, 김용식 and 이영한. "Phosphorylation of glycogen synthase kinase-3β at serine-9 by phospholipase Cγ1 through protein kinase C in rat 3Y1 fibroblasts" Experimental and Molecular Medicine 34, no.6 (2002) : 444-450.