@article{ART001076982,
author={Eun Jeong Lee and 최은미 and So Ra Kim and Jung Hea Park and Hyunsook Kim and Kwon Soo Ha and Young Myeong Kim and Sung Soo Kim and Myeon Choe and 김종일 and Jeong A Han},
title={Cyclooxygenase-2 promotes cell proliferation, migration andinvasion in U2OS human osteosarcoma cells},
journal={Experimental and Molecular Medicine},
issn={1226-3613},
year={2007},
volume={39},
number={4},
pages={469-476}
}

TY - JOUR
AU - Eun Jeong Lee
AU - 최은미
AU - So Ra Kim
AU - Jung Hea Park
AU - Hyunsook Kim
AU - Kwon Soo Ha
AU - Young Myeong Kim
AU - Sung Soo Kim
AU - Myeon Choe
AU - 김종일
AU - Jeong A Han
TI - Cyclooxygenase-2 promotes cell proliferation, migration andinvasion in U2OS human osteosarcoma cells
T2 - Experimental and Molecular Medicine
JO - Experimental and Molecular Medicine
PY - 2007
VL - 39
IS - 4
PB - 생화학분자생물학회
SP - 469
EP - 476
SN - 1226-3613
AB - Osteosarcoma is the most comon primary bone tu-mor, but the pathogenesis is not well understood. While cyclooxygeanse-2 (COX-2) is known to be close-ly associated with tumor growth and metastasis in sev-eral kinds of human tumors, the function of COX-2 in osteosarcoma is unclear. Therefore, to investigate the function of COX-2 in osteosarcoma, we established stable cell lines overexpressing COX-2 in U2OS human osteosarcoma cells. COX-2 overexpression as well as prostaglandin E2 treatment promoted proliferation of U2OS cells. In addition, COX-2 overexpression enhanced mobility and invasiveness of U2OS cells, which was accompanied by increases of matrix metalloproteinase- 2 and -9 (MMP-2 and -9) activities. Selective COX-2 inhibitors, NS-398 and celecoxib, inhibited cell proliferation and abrogated the enhanced mobility, invasiveness and MMP activities induced by COX-2 overexpression. These results suggest that COX-2 is directly associated with cell proliferation, migrationand invasion in human osteosarcoma cells, and the therapeutic value of COX-2 inhibitors should be evaluated continuously.
KW - cell movement; cell proliferation; cyclo-oproteinases; osteosarco-ma
DO -
UR -
ER -

Eun Jeong Lee, 최은미, So Ra Kim, Jung Hea Park, Hyunsook Kim, Kwon Soo Ha, Young Myeong Kim, Sung Soo Kim, Myeon Choe, 김종일 and Jeong A Han. 2007, "Cyclooxygenase-2 promotes cell proliferation, migration andinvasion in U2OS human osteosarcoma cells", Experimental and Molecular Medicine, vol.39, no.4 pp.469-476.

Eun Jeong Lee, 최은미, So Ra Kim, Jung Hea Park, Hyunsook Kim, Kwon Soo Ha, Young Myeong Kim, Sung Soo Kim, Myeon Choe, 김종일, Jeong A Han "Cyclooxygenase-2 promotes cell proliferation, migration andinvasion in U2OS human osteosarcoma cells" Experimental and Molecular Medicine 39.4 pp.469-476 (2007) : 469.

Eun Jeong Lee, 최은미, So Ra Kim, Jung Hea Park, Hyunsook Kim, Kwon Soo Ha, Young Myeong Kim, Sung Soo Kim, Myeon Choe, 김종일, Jeong A Han. Cyclooxygenase-2 promotes cell proliferation, migration andinvasion in U2OS human osteosarcoma cells. 2007; 39(4), 469-476.

Eun Jeong Lee, 최은미, So Ra Kim, Jung Hea Park, Hyunsook Kim, Kwon Soo Ha, Young Myeong Kim, Sung Soo Kim, Myeon Choe, 김종일 and Jeong A Han. "Cyclooxygenase-2 promotes cell proliferation, migration andinvasion in U2OS human osteosarcoma cells" Experimental and Molecular Medicine 39, no.4 (2007) : 469-476.

Eun Jeong Lee; 최은미; So Ra Kim; Jung Hea Park; Hyunsook Kim; Kwon Soo Ha; Young Myeong Kim; Sung Soo Kim; Myeon Choe; 김종일; Jeong A Han. Cyclooxygenase-2 promotes cell proliferation, migration andinvasion in U2OS human osteosarcoma cells. Experimental and Molecular Medicine, 39(4), 469-476.

Eun Jeong Lee; 최은미; So Ra Kim; Jung Hea Park; Hyunsook Kim; Kwon Soo Ha; Young Myeong Kim; Sung Soo Kim; Myeon Choe; 김종일; Jeong A Han. Cyclooxygenase-2 promotes cell proliferation, migration andinvasion in U2OS human osteosarcoma cells. Experimental and Molecular Medicine. 2007; 39(4) 469-476.

Eun Jeong Lee, 최은미, So Ra Kim, Jung Hea Park, Hyunsook Kim, Kwon Soo Ha, Young Myeong Kim, Sung Soo Kim, Myeon Choe, 김종일, Jeong A Han. Cyclooxygenase-2 promotes cell proliferation, migration andinvasion in U2OS human osteosarcoma cells. 2007; 39(4), 469-476.

Eun Jeong Lee, 최은미, So Ra Kim, Jung Hea Park, Hyunsook Kim, Kwon Soo Ha, Young Myeong Kim, Sung Soo Kim, Myeon Choe, 김종일 and Jeong A Han. "Cyclooxygenase-2 promotes cell proliferation, migration andinvasion in U2OS human osteosarcoma cells" Experimental and Molecular Medicine 39, no.4 (2007) : 469-476.