@article{ART001100085,
author={원선미 and 박연희 and 김희정 and 박권무 and 이원정},
title={Catechins inhibit angiotensin II-induced vascular smooth muscle cell proliferation via mitogen-activated protein kinase pathway},
journal={Experimental and Molecular Medicine},
issn={1226-3613},
year={2006},
volume={38},
number={5},
pages={525-534}
}

TY - JOUR
AU - 원선미
AU - 박연희
AU - 김희정
AU - 박권무
AU - 이원정
TI - Catechins inhibit angiotensin II-induced vascular smooth muscle cell proliferation via mitogen-activated protein kinase pathway
T2 - Experimental and Molecular Medicine
JO - Experimental and Molecular Medicine
PY - 2006
VL - 38
IS - 5
PB - 생화학분자생물학회
SP - 525
EP - 534
SN - 1226-3613
AB - Catechins, components of green tea, reduce the incidence of cardiovascular diseases such as atherosclerosis. Angiotensin II (Ang II) is highly implicated in the prolifmuscle cells (VSMC), resulting in atherosclerosis. The acting mechanisms of the catechins remain to be defined in the proliferation of VSMC induced by Ang II. Here we report that catechin, epicatechin (EC), epicatechingallate (ECG) or epigallocatechingallate (EGCG) significantly inhibits the Ang II-induced [3H]thymidine incorporation into the primary cultured rat aortic VSMC. Ang II increases the phosphorylation of the extracellular signal-regulat-ed protein kinase 1/2 (ERK 1/2), c-jun-N-terminal kinase 1/2 (JNK 1/2), or p38 mitogen-activated protein kinases (MAPKs) and mRNA expression of c-jun and c-fos. The EGCG pretreatment inhibits the Ang
KW - angiotensin I; catechin; mitogen-acti-vated protein kinase; muscle, smooth, vascular; pro-to-oncogene proteins c-fos; proto-oncogene proteins c-jun
DO -
UR -
ER -

원선미, 박연희, 김희정, 박권무 and 이원정. 2006, "Catechins inhibit angiotensin II-induced vascular smooth muscle cell proliferation via mitogen-activated protein kinase pathway", Experimental and Molecular Medicine, vol.38, no.5 pp.525-534.

원선미, 박연희, 김희정, 박권무, 이원정 "Catechins inhibit angiotensin II-induced vascular smooth muscle cell proliferation via mitogen-activated protein kinase pathway" Experimental and Molecular Medicine 38.5 pp.525-534 (2006) : 525.

원선미, 박연희, 김희정, 박권무, 이원정. Catechins inhibit angiotensin II-induced vascular smooth muscle cell proliferation via mitogen-activated protein kinase pathway. 2006; 38(5), 525-534.

원선미, 박연희, 김희정, 박권무 and 이원정. "Catechins inhibit angiotensin II-induced vascular smooth muscle cell proliferation via mitogen-activated protein kinase pathway" Experimental and Molecular Medicine 38, no.5 (2006) : 525-534.

원선미; 박연희; 김희정; 박권무; 이원정. Catechins inhibit angiotensin II-induced vascular smooth muscle cell proliferation via mitogen-activated protein kinase pathway. Experimental and Molecular Medicine, 38(5), 525-534.

원선미; 박연희; 김희정; 박권무; 이원정. Catechins inhibit angiotensin II-induced vascular smooth muscle cell proliferation via mitogen-activated protein kinase pathway. Experimental and Molecular Medicine. 2006; 38(5) 525-534.

원선미, 박연희, 김희정, 박권무, 이원정. Catechins inhibit angiotensin II-induced vascular smooth muscle cell proliferation via mitogen-activated protein kinase pathway. 2006; 38(5), 525-534.

원선미, 박연희, 김희정, 박권무 and 이원정. "Catechins inhibit angiotensin II-induced vascular smooth muscle cell proliferation via mitogen-activated protein kinase pathway" Experimental and Molecular Medicine 38, no.5 (2006) : 525-534.