@article{ART001385786,
author={Jun Hee Lim and Hee Jung Um and Jong-Wook Park and 이인규 and 권택규},
title={Interleukin-1β promotes the expression of monocyte chemoattractant protein-1 in human aorta smooth muscle cells via multiple signaling pathways},
journal={Experimental and Molecular Medicine},
issn={1226-3613},
year={2009},
volume={41},
number={10},
pages={757-764}
}

TY - JOUR
AU - Jun Hee Lim
AU - Hee Jung Um
AU - Jong-Wook Park
AU - 이인규
AU - 권택규
TI - Interleukin-1β promotes the expression of monocyte chemoattractant protein-1 in human aorta smooth muscle cells via multiple signaling pathways
T2 - Experimental and Molecular Medicine
JO - Experimental and Molecular Medicine
PY - 2009
VL - 41
IS - 10
PB - 생화학분자생물학회
SP - 757
EP - 764
SN - 1226-3613
AB - Monocyte chemoattractant protein-1 (MCP1) plays a key role in monocyte/macrophage infiltration to the sub-endothelial space of the blood vessel wall, which is a critical initial step in atherosclerosis. In this study, we examined the intracellular signaling pathway of IL-1β-induced MCP1 expression using various chemical inhibitors. The pretreatment of a phosphatidylcholine (PC)-specific PLC (PC-PLC) inhibitor (D609), PKC inhibitors, or an NF-κB inhibitor completely suppressed the IL-1β-induced MCP1 expression through blocking NF-κB translocation to the nucleus. Pretreatment with inhibitors of tyrosine kinase or PLD partially suppressed MCP1 expression and failed to block nuclear NF-κB translocation. These results suggest that IL-1β induces MCP1 expression through activation of NF-κB via the PC-PLC/PKC signaling pathway.
KW - aorta, atherosclerosis, CCL2 protein, human, interleukin-1β, myocytes, smooth muscle, NF-κB, protein kinase C, type C phospholipase
DO -
UR -
ER -

Jun Hee Lim, Hee Jung Um, Jong-Wook Park, 이인규 and 권택규. 2009, "Interleukin-1β promotes the expression of monocyte chemoattractant protein-1 in human aorta smooth muscle cells via multiple signaling pathways", Experimental and Molecular Medicine, vol.41, no.10 pp.757-764.

Jun Hee Lim, Hee Jung Um, Jong-Wook Park, 이인규, 권택규 "Interleukin-1β promotes the expression of monocyte chemoattractant protein-1 in human aorta smooth muscle cells via multiple signaling pathways" Experimental and Molecular Medicine 41.10 pp.757-764 (2009) : 757.

Jun Hee Lim, Hee Jung Um, Jong-Wook Park, 이인규, 권택규. Interleukin-1β promotes the expression of monocyte chemoattractant protein-1 in human aorta smooth muscle cells via multiple signaling pathways. 2009; 41(10), 757-764.

Jun Hee Lim, Hee Jung Um, Jong-Wook Park, 이인규 and 권택규. "Interleukin-1β promotes the expression of monocyte chemoattractant protein-1 in human aorta smooth muscle cells via multiple signaling pathways" Experimental and Molecular Medicine 41, no.10 (2009) : 757-764.

Jun Hee Lim; Hee Jung Um; Jong-Wook Park; 이인규; 권택규. Interleukin-1β promotes the expression of monocyte chemoattractant protein-1 in human aorta smooth muscle cells via multiple signaling pathways. Experimental and Molecular Medicine, 41(10), 757-764.

Jun Hee Lim; Hee Jung Um; Jong-Wook Park; 이인규; 권택규. Interleukin-1β promotes the expression of monocyte chemoattractant protein-1 in human aorta smooth muscle cells via multiple signaling pathways. Experimental and Molecular Medicine. 2009; 41(10) 757-764.

Jun Hee Lim, Hee Jung Um, Jong-Wook Park, 이인규, 권택규. Interleukin-1β promotes the expression of monocyte chemoattractant protein-1 in human aorta smooth muscle cells via multiple signaling pathways. 2009; 41(10), 757-764.

Jun Hee Lim, Hee Jung Um, Jong-Wook Park, 이인규 and 권택규. "Interleukin-1β promotes the expression of monocyte chemoattractant protein-1 in human aorta smooth muscle cells via multiple signaling pathways" Experimental and Molecular Medicine 41, no.10 (2009) : 757-764.