@article{ART001743094,
author={Yeong-Min Park and Kyung Tae Noh and Young-Il Jeong and 정인덕 and 강현규 and Gil Sun Cha and Su Jung Lee and Jong Keun Seo and Dae Hwan Kang and 황태호 and 이은경 and Byungsuk Kwon and 박영민},
title={Rhamnogalacturonan II is a Toll-like receptor 4 agonist that inhibits tumor growth by activating dendritic cell-mediated CD8þ T cells},
journal={Experimental and Molecular Medicine},
issn={1226-3613},
year={2013},
volume={45},
number={2},
pages={1-11}
}

TY - JOUR
AU - Yeong-Min Park
AU - Kyung Tae Noh
AU - Young-Il Jeong
AU - 정인덕
AU - 강현규
AU - Gil Sun Cha
AU - Su Jung Lee
AU - Jong Keun Seo
AU - Dae Hwan Kang
AU - 황태호
AU - 이은경
AU - Byungsuk Kwon
AU - 박영민
TI - Rhamnogalacturonan II is a Toll-like receptor 4 agonist that inhibits tumor growth by activating dendritic cell-mediated CD8þ T cells
T2 - Experimental and Molecular Medicine
JO - Experimental and Molecular Medicine
PY - 2013
VL - 45
IS - 2
PB - 생화학분자생물학회
SP - 1
EP - 11
SN - 1226-3613
AB - We evaluated the effectiveness of rhamnogalacturonan II (RG-II)-stimulated bone marrow-derived dendritic cells (BMDCs)vaccination on the induction of antitumor immunity in a mouse lymphoma model using EG7-lymphoma cells expressing ovalbumin (OVA). BMDCs treated with RG-II had an activated phenotype. RG-II induced interleukin (IL)-12, IL-1b, tumor necrosis factor-a (TNF-a) and interferon-c (IFN-c) production during dendritic cell (DC) maturation. BMDCs stimulated with RG-II facilitate the proliferation of CD8þ T cells. Using BMDCs from the mice deficient in Toll-like receptors (TLRs), we revealed that RG-II activity is dependent on TLR4. RG-II showed a preventive effect of immunization with OVA-pulsed BMDCs against EG7 lymphoma. These results suggested that RG-II expedites the DC-based immune response through the TLR4signaling pathway.
KW - adjuvant; dendritic cells; rhamnogalacturonan II; Toll-like receptor 4; tumor
DO -
UR -
ER -

Yeong-Min Park, Kyung Tae Noh, Young-Il Jeong, 정인덕, 강현규, Gil Sun Cha, Su Jung Lee, Jong Keun Seo, Dae Hwan Kang, 황태호, 이은경, Byungsuk Kwon and 박영민. 2013, "Rhamnogalacturonan II is a Toll-like receptor 4 agonist that inhibits tumor growth by activating dendritic cell-mediated CD8þ T cells", Experimental and Molecular Medicine, vol.45, no.2 pp.1-11.

Yeong-Min Park, Kyung Tae Noh, Young-Il Jeong, 정인덕, 강현규, Gil Sun Cha, Su Jung Lee, Jong Keun Seo, Dae Hwan Kang, 황태호, 이은경, Byungsuk Kwon, 박영민 "Rhamnogalacturonan II is a Toll-like receptor 4 agonist that inhibits tumor growth by activating dendritic cell-mediated CD8þ T cells" Experimental and Molecular Medicine 45.2 pp.1-11 (2013) : 1.

Yeong-Min Park, Kyung Tae Noh, Young-Il Jeong, 정인덕, 강현규, Gil Sun Cha, Su Jung Lee, Jong Keun Seo, Dae Hwan Kang, 황태호, 이은경, Byungsuk Kwon, 박영민. Rhamnogalacturonan II is a Toll-like receptor 4 agonist that inhibits tumor growth by activating dendritic cell-mediated CD8þ T cells. 2013; 45(2), 1-11.

Yeong-Min Park, Kyung Tae Noh, Young-Il Jeong, 정인덕, 강현규, Gil Sun Cha, Su Jung Lee, Jong Keun Seo, Dae Hwan Kang, 황태호, 이은경, Byungsuk Kwon and 박영민. "Rhamnogalacturonan II is a Toll-like receptor 4 agonist that inhibits tumor growth by activating dendritic cell-mediated CD8þ T cells" Experimental and Molecular Medicine 45, no.2 (2013) : 1-11.

Yeong-Min Park; Kyung Tae Noh; Young-Il Jeong; 정인덕; 강현규; Gil Sun Cha; Su Jung Lee; Jong Keun Seo; Dae Hwan Kang; 황태호; 이은경; Byungsuk Kwon; 박영민. Rhamnogalacturonan II is a Toll-like receptor 4 agonist that inhibits tumor growth by activating dendritic cell-mediated CD8þ T cells. Experimental and Molecular Medicine, 45(2), 1-11.

Yeong-Min Park; Kyung Tae Noh; Young-Il Jeong; 정인덕; 강현규; Gil Sun Cha; Su Jung Lee; Jong Keun Seo; Dae Hwan Kang; 황태호; 이은경; Byungsuk Kwon; 박영민. Rhamnogalacturonan II is a Toll-like receptor 4 agonist that inhibits tumor growth by activating dendritic cell-mediated CD8þ T cells. Experimental and Molecular Medicine. 2013; 45(2) 1-11.

Yeong-Min Park, Kyung Tae Noh, Young-Il Jeong, 정인덕, 강현규, Gil Sun Cha, Su Jung Lee, Jong Keun Seo, Dae Hwan Kang, 황태호, 이은경, Byungsuk Kwon, 박영민. Rhamnogalacturonan II is a Toll-like receptor 4 agonist that inhibits tumor growth by activating dendritic cell-mediated CD8þ T cells. 2013; 45(2), 1-11.

Yeong-Min Park, Kyung Tae Noh, Young-Il Jeong, 정인덕, 강현규, Gil Sun Cha, Su Jung Lee, Jong Keun Seo, Dae Hwan Kang, 황태호, 이은경, Byungsuk Kwon and 박영민. "Rhamnogalacturonan II is a Toll-like receptor 4 agonist that inhibits tumor growth by activating dendritic cell-mediated CD8þ T cells" Experimental and Molecular Medicine 45, no.2 (2013) : 1-11.