@article{ART002115357,
author={하정민 and 백승훈 and 김영환 and 진서연 and 이혜선 and 김선자 and 신화경 and 이동형 and 송상헌 and 김치대 and 배순식},
title={Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway},
journal={Experimental and Molecular Medicine},
issn={1226-3613},
year={2016},
volume={48},
pages={1-8}
}

TY - JOUR
AU - 하정민
AU - 백승훈
AU - 김영환
AU - 진서연
AU - 이혜선
AU - 김선자
AU - 신화경
AU - 이동형
AU - 송상헌
AU - 김치대
AU - 배순식
TI - Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway
T2 - Experimental and Molecular Medicine
JO - Experimental and Molecular Medicine
PY - 2016
VL - 48
IS - null
PB - 생화학분자생물학회
SP - 1
EP - 8
SN - 1226-3613
AB - Angiogenesis has an essential role in many pathophysiologies. Here, we show that phospholipase C-β3 (PLC-β3) isoform regulates endothelial cell function and retinal angiogenesis. Silencing of PLC-β3 in human umbilical vein endothelial cells (HUVECs) significantly delayed proliferation, migration and capillary-like tube formation. In addition, mice lacking PLC-β3 showed impaired retinal angiogenesis with delayed endothelial proliferation, reduced endothelial cell activation, abnormal vessel formation and hemorrhage. Finally, tumor formation was significantly reduced in mice lacking PLC-β3 and showed irregular size and shape of blood vessels. These results suggest that regulation of endothelial function by PLC-β3 may contribute to angiogenesis.
KW -
DO -
UR -
ER -

하정민, 백승훈, 김영환, 진서연, 이혜선, 김선자, 신화경, 이동형, 송상헌, 김치대 and 배순식. 2016, "Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway", Experimental and Molecular Medicine, vol.48, pp.1-8.

하정민, 백승훈, 김영환, 진서연, 이혜선, 김선자, 신화경, 이동형, 송상헌, 김치대, 배순식 "Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway" Experimental and Molecular Medicine 48 pp.1-8 (2016) : 1.

하정민, 백승훈, 김영환, 진서연, 이혜선, 김선자, 신화경, 이동형, 송상헌, 김치대, 배순식. Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway. 2016; 48 1-8.

하정민, 백승훈, 김영환, 진서연, 이혜선, 김선자, 신화경, 이동형, 송상헌, 김치대 and 배순식. "Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway" Experimental and Molecular Medicine 48(2016) : 1-8.

하정민; 백승훈; 김영환; 진서연; 이혜선; 김선자; 신화경; 이동형; 송상헌; 김치대; 배순식. Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway. Experimental and Molecular Medicine, 48, 1-8.

하정민; 백승훈; 김영환; 진서연; 이혜선; 김선자; 신화경; 이동형; 송상헌; 김치대; 배순식. Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway. Experimental and Molecular Medicine. 2016; 48 1-8.

하정민, 백승훈, 김영환, 진서연, 이혜선, 김선자, 신화경, 이동형, 송상헌, 김치대, 배순식. Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway. 2016; 48 1-8.

하정민, 백승훈, 김영환, 진서연, 이혜선, 김선자, 신화경, 이동형, 송상헌, 김치대 and 배순식. "Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway" Experimental and Molecular Medicine 48(2016) : 1-8.