초록 열기/닫기 버튼
Purpose: Although discussion about active treatment of trisomy 18 is increasing,there are no previous articles regarding this subject in Korea. In order to provideobjective data about the clinical characteristics and survival of patients with trisomy18, based on the treatment policy, to medical teams and parents with trisomy 18, wereviewed the medical records of such patients at a single center in Korea. Methods: This is a retrospective study of 22 patients diagnosed with trisomy 18 at theSamsung Medical Center between 1995 and 2013. We collected data about the clinicalcharacteristics, including demographics, birth history, diagnosis method, and associatedanomalies. We analyzed the survival in days, according to three broad categoriesof treatment policy: give-up, conservative management and active treatment. Results: Of the 22 patients with confirmed trisomy 18, the majority were female (19,86%). The median gestational age was 39 weeks (range, 31–41 weeks) and the medianbirth weight is 2,029 g (range, 1,130–2,990 g). Among the anomalies associated withtrisomy 18, ventricular septal defect (86%) and patent ductus arteriosus (81%) werethe most common cardiac anomalies; giant cisterna magna (59%) was the mostcommon central nervous system anomaly; and clenched hands (73%) and low setears (59%) were the most common structural anomalies. The survival based on thetreatment policy was the highest in the active treatment group, followed by theconservative management group. The give-up group had the lowest survival. Conclusion: It is possible to achieve an improvement in both survival and symptomrelief for patients with trisomy 18, despite poor neurological outcome and highmortality. Medical personnel need to provide objective data on trisomy 18 to theparents, and determine the treatment policy through careful discussion.
