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Background/Aims: The objective of our study was to identifyuseful computed tomography (CT) findings for differentiatingfundal type adenomyomatosis from localized chronic cholecystitisinvolving the fundus of the gallbladder. Methods: Weretrospectively identified cases of 41 patients with pathologicallyproven adenomyomatosis (n=21) or chronic cholecystitis(n=20) who had fundal thickening of the gallbladderon preoperative abdominal CT. Analysis of the CT findingsincluded evaluation of the thickness, contour, border, intralesionalcystic area, adjacent gallbladder wall thickening,presence of inner layer enhancement, enhancement grade,enhancement pattern, and presence of stones. Statisticalanalyses were performed using the Mann-Whitney U test andFisher exact test. Results: Oval contour, inner layer enhancementand intralesional cystic area were more frequentlynoted in adenomyomatosis than in chronic cholecystitis(p<0.05 for each finding). Flat contour and adjacent gallbladderwall thickening were more frequently observed in chroniccholecystitis than in adenomyomatosis. No differences betweenadenomyomatosis and chronic cholecystitis in termsof the thickness, enhancement grade, enhancement patternand presence of stones were apparent. Conclusions: CTmay help to differentiate fundal type adenomyomatosis fromlocalized chronic cholecystitis involving the fundus of the gallbladder.