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Background/Aims: Programmed death-1 (PD-1) expressionwas investigated in CD4+ and CD8+ T cells from hepatitis Bvirus (HBV)-infected patients at the chronic hepatitis B (CHB)infection, liver cirrhosis (LC), and hepatocellular carcinoma(HCC) stages. Methods: PD-1 expression in circulating CD4+and CD8+ T cells was detected by flow cytometry. The correlationsbetween PD-1 expression and HBV viral load, alanineaminotransaminase (ALT) levels and aspartate aminotransferase(AST) levels were analyzed using GraphPad Prism5.0. Results: PD-1 expression in CD4+ and CD8+ T cells wassignificantly increased in both the CHB group and advancedstagegroup (LC plus HCC). In the CHB group, PD-1 expressionin both CD4+ and CD8+ T cells was positively correlatedwith the HBV viral load, ALT, and AST levels. However, in theLC plus HCC group, significant correlations between PD-1expression and the clinical parameters were nearly absent. Conclusions: PD-1 expression in peripheral CD4+ and CD8+T cells is dynamic, changes with HBV infection progression,and is related to HBV viral load and liver function, especiallyin CHB. PD-1 expression could be utilized as a potential clinicalindicator to determine the extent of virus replication andliver injury.
