초록 열기/닫기 버튼
Many viruses, including viral hemorrhagic septicemia virus (VHSV), initiate oxidative stresses such as generation of ROS, and the depletion of reduced thiols in virus infected cells. In this study, epigallocatechingallate (EGCG) showed the highest antiviral activities against the VHSV. The cell viability of EGCG was exposed to 1.4 times higher than any that of the other catechins at 100 μM compared to the control. The DNA fragmentation and ROS generation inhibition effect of EGCG in FHM cells, upon exposure to 0.2 moi VHSV for 42 h was examined. In regard to the cellular redox status and oxidative DNA damage to FHM cells infected with the VHSV, a treatment with 100 μM EGCG produced a 1.3-fold lower ROS generation and DNA fragmentation than the control, indicating that EGCG may increase the cell viability by suppressing the oxidative stress induced by a virus infection.
