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This paper aims to show Empedocles’ influence on Hippocratic medicine through the analysis of two Hippocratic writings, i.e. On Ancient Medicine(AM) and On the Nature of Man(NM). I think that the author of AM criticizes philosophical physicians or natural philosophers, especially Empedocles, that at least Empedoclean philosophy is not necessary to medicine. On the contrary, the author of NM positively receives Empedoclean position in several aspects. It is necessary to examine these two writings in order to consider Empedocles’ positive and negative influences on Hippocratic Medicine. The author of AM attacks the philosophical physicians who lay down as a hypothesis for their account hot or cold or wet or dry, in other words the same one or two things as the primary cause of all diseases. But it does not seem clear what the point of his criticism is. I think that his criticism lies on the following three points: (1) Hot or cold or wet or dry is neither the important cause of disease nor the important element for therapy; (2) The cause of diseases is not the same one or two things, but myriadthings; (3) hypothesis as assumption is not necessary to medicine. Thesethree points implies the criticism against cosmology and methodology ofsome early Greek philosophers, in particular Empedocles. Accordingly weshould notice that the author attacks physicians influenced by Empedoclesespecially. Then whom does attack the author of AM? Lloyd points out Philolaus asthe author’s opponent, since he argues that man consists of the hot(Lloyd,1963: 124-25). But I think that Lloyd narrowed down the opponent’s rangeexcessively. For example, if a physician holds that we consist of hot, cold,dry and wet, and that these are causes of diseases, does he belong tothose whom the author attacked, or not? At a glance he doesn’t seem todo. Because he lays down not one or two things as the cause of diseases,but four. But strictly we should tell that he does only two. Because hotand cold are contrary, and so both can not be causes of an disease at thesame time. The same account applies to dry and wet too. Therefore even ifsomeone lays down hot, cold, dry and wet as causes of diseases, it is rightto regard him as the author’s opponent. Moreover if a physician explainsdiseases by hot or cold or dry or wet, whether these are substances orqualities, in my opinion he is the author’s opponent. Thus the opponents’range can be enlarged. While the author of AM attempts to exclude Empedoclean thought frommedicine, the author of NM adopts it so positively. This author rejects themonistic view about man in chapters 1 and 2, and in chapter 3 tells that manis composed of hot, cold, dry and wet. And in the subsequent chapters heargues that man’s body is composed of the four humours, and associateseach humour with hot, cold, dry and wet respectively. It is noticeablethat the author takes the pluralistic view and thinks that elements are fourin number, that he make much of hot, cold, dry and wet, and that heexplains man’ generation and health by the balanced mixture. This showsEmpedocles’ influence on the author. In addition, the author holds that man and cosmos have hot, cold, dry and wet equally, and their change incosmos according to seasons brings the increase or decrease of humours toman’s body. Here is Empedocles’ theory of macrocosm-microcosm found.