@article{ART001634207,
author={강경훈},
title={CpG Island Hypermethylation in Gastric Carcinoma and Its Premalignant Lesions},
journal={Journal of Pathology and Translational Medicine},
issn={2383-7837},
year={2012},
volume={46},
number={1},
pages={1-9}
}

TY - JOUR
AU - 강경훈
TI - CpG Island Hypermethylation in Gastric Carcinoma and Its Premalignant Lesions
T2 - Journal of Pathology and Translational Medicine
JO - Journal of Pathology and Translational Medicine
PY - 2012
VL - 46
IS - 1
PB - 대한병리학회
SP - 1
EP - 9
SN - 2383-7837
AB - Gastric cancers arise through a multistep process characterized by the progressive accumulation of molecular alterations in which genetic and epigenetic mechanisms have been implicated. Gastric cancer is one of the human malignancies in which aberrant promoter CpG island hypermethylation is frequently found. Helicobacter pylori and Epstein-Barr virus, which are known carcinogens for gastric cancer, are closely associated with enhanced hypermethylation of CpG island loci in gastric non-neoplastic epithelial cells and cancer cells, respectively. Aberrant CpG island hypermethylation occurs early in the multistep cascade of gastric carcinogenesis and tends to increase with the step-wise progression of the lesion. Approximately 400 genes that are actively expressed in normal gastric epithelial cells are estimated to be inactivated in gastric cancers as a result of promoter CpG island hypermethylation. In this review, a variety of information is summarized regarding CpG island hypermethylation in gastric cancer.
KW - CpG island, DNA methylation, Gastric cancer, Intestinal metaplasia
DO -
UR -
ER -

강경훈. 2012, "CpG Island Hypermethylation in Gastric Carcinoma and Its Premalignant Lesions", Journal of Pathology and Translational Medicine, vol.46, no.1 pp.1-9.

강경훈 "CpG Island Hypermethylation in Gastric Carcinoma and Its Premalignant Lesions" Journal of Pathology and Translational Medicine 46.1 pp.1-9 (2012) : 1.

강경훈. CpG Island Hypermethylation in Gastric Carcinoma and Its Premalignant Lesions. 2012; 46(1), 1-9.

강경훈. "CpG Island Hypermethylation in Gastric Carcinoma and Its Premalignant Lesions" Journal of Pathology and Translational Medicine 46, no.1 (2012) : 1-9.

강경훈. CpG Island Hypermethylation in Gastric Carcinoma and Its Premalignant Lesions. Journal of Pathology and Translational Medicine, 46(1), 1-9.

강경훈. CpG Island Hypermethylation in Gastric Carcinoma and Its Premalignant Lesions. Journal of Pathology and Translational Medicine. 2012; 46(1) 1-9.

강경훈. CpG Island Hypermethylation in Gastric Carcinoma and Its Premalignant Lesions. 2012; 46(1), 1-9.

강경훈. "CpG Island Hypermethylation in Gastric Carcinoma and Its Premalignant Lesions" Journal of Pathology and Translational Medicine 46, no.1 (2012) : 1-9.