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We examined the effect of a endurance low intensity exercise on the protein and isozyme expression of the monocarboxylate transporters MCT1, MCT4 and LDH in streptozotocin-induced diabetic rat' soleus and gastrocnemius. Muscle samples were obtained at rest after 4 weeks treadmill exercise (5~8 m min^(-1), 0%grade). LDH isozyme activity were significantly increased in soleus and gastrocnemius in diabetic groups with training (p < .05). The expression of two MCTs was examined in skeletal muscle. MCT1 and MCT4 proteins are coexpressed in rat skeletal muscles. MCT1 proteins in soleus and MCT4 in gastrocnemius of diabetic groups with exercise were significantly increased than diabetic groups (p < .05). The present data suggested that MCT1 and MCT4 proteins are up-regulated by a endurance low intensity exercise training. Thus MCT1 and MCT4 belong to a class of selected metabolic factors that are up-regulated with an exercise stimulus.
