목적: 만성 골반통은 고식적인 치료방법으로는 완전히 조절되지 않는 골반통을 의미한다. 만성 골반통은 면역 작용의 변화가 관련이 있다고 알려져 있는데, 미슬토 추출물은 면역작용을 조절하는 효과가 있다. 본 연구에서는 고식적인 치료방법으로 잘 조절되지 않는 만성골반통에서 미슬토 추출물이 통증을 경감시키는 효과가 있는지에 대하여 조사해 보았다. 연구 방법: 만성 골반통을 주소로 전남대학교병원 산부인과 외래를 내원한 58명의 환자를 대상으로 하여 미슬토 추출물 5 mg을 5주 동안 일주일에 3회씩 피하주사하고, 통증의 변화와 단기간의 합병증을 관찰하였다. 결과: 58명 중 2명 (0.03 %)의 환자들은 심한 전신적인 부작용이 일어나 치료를 중단하였다. 나머지 56명중 48명 (85.7%)은 통증이 완화되었다. 56명 중 40명 (69%)은 가벼운 소양증이나 미열과 같은 부작용이 있었고, 항히스타민제나 대증적 치료로 호전되었다. 치료 후 6개월 후까지 추적이 가능했던 환자는 10명이었는데 이중 4명은 전신적인 소양증과 쉽게 감기에 걸리는 등의 부작용이 있었다. 결론: 일반적인 치료로는 잘 조절되지 않는 만성 골반통에서 미슬토 추출물의 피하주사를 하는 경우 통증이 감소하여 치료에 도움이 될 수 있다. 그러나 향후 더 많은 환자에서의 연구와 장기간의 부작용에 대한 조사가 필요할 것으로 사료된다.

Objective: Chronic pelvic pain is pelvic pain which is not completely controlled by classical treatments. In many reports, immune alternation is related to original diseases that induce the chronic pelvic pain. Mistletoe extract has been known that it has immune modulation effect. Therefore the purpose of this study is to determine the pain-reducing effects of mistletoe extract for chronic pelvic pain that is not controlled by classical treatments. Methods: The fitty-eight patients who visited to outpatient department of Department of Obstetrics & Gynecology, Chonnam National University Hospital due to chronic pelvic pain. Mistletoe extract (Helixor-AⓇ) 5-10 mg was injected subcutaneously 3 times per week for 5 weeks, and the change of pain and short-term side-effects after injections were observed. In patients after 6 month of follow-up, the change of pain and long-term side-effects were also observed. Results: In 2 of 58 patients (0.03%), treatments were discontinued doe to severe general side effect. In 48 of 56 patients (85.7%), chronic pelvic pains were improved. In 40 of 56 patients (69%), mild side effects as like mild itching were appeared and they were easily controlled by anti-histamines and conservative treatments. In 6 months after injection, general itching sensation and easily catched common cold were complaint in 4 of 10 patients. Conclusion: The subcutaneous injection of mistletoe extract may effective treatment method for the chronic pelvic pain that is not controlled by classical treatment. However more studies about log-term effect of mistletoe therapy are needed.

Objective: Chronic pelvic pain is pelvic pain which is not completely controlled by classical treatments. In many reports, immune alternation is related to original diseases that induce the chronic pelvic pain. Mistletoe extract has been known that it has immune modulation effect. Therefore the purpose of this study is to determine the pain-reducing effects of mistletoe extract for chronic pelvic pain that is not controlled by classical treatments. Methods: The fitty-eight patients who visited to outpatient department of Department of Obstetrics & Gynecology, Chonnam National University Hospital due to chronic pelvic pain. Mistletoe extract (Helixor-AⓇ) 5-10 mg was injected subcutaneously 3 times per week for 5 weeks, and the change of pain and short-term side-effects after injections were observed. In patients after 6 month of follow-up, the change of pain and long-term side-effects were also observed. Results: In 2 of 58 patients (0.03%), treatments were discontinued doe to severe general side effect. In 48 of 56 patients (85.7%), chronic pelvic pains were improved. In 40 of 56 patients (69%), mild side effects as like mild itching were appeared and they were easily controlled by anti-histamines and conservative treatments. In 6 months after injection, general itching sensation and easily catched common cold were complaint in 4 of 10 patients. Conclusion: The subcutaneous injection of mistletoe extract may effective treatment method for the chronic pelvic pain that is not controlled by classical treatment. However more studies about log-term effect of mistletoe therapy are needed.

Chronic pelvic pain, Mistletoe extract