목적: Unsatisfactory colposcopy 소견이면서 ASCUS나 LSIL이 보고된 폐경여성에서 고등급 자궁경부병변을 예측하는데 HPV viral load 값이 도움이 되는지 평가하였다. 방법: HPV 검사가 양성이면서 ASCUS나 LSIL이 보고된 폐경여성들 중 진단적 conization을 시행한 54명을 분석하였다. HPV검 사는 hybrid capture II을 이용하였다. 자궁경부의 조직학적 결과에 따라 저위험군 (만성자궁경부염, CIN I)과 고위험군 (≥CIN II)으로 나누었다. Viral load값에 따라 100 RLU/PC 미만인 군과 100 RLU/PC 이상인 군으로 나누었고 각 군의 자궁경부 병변 들을 서로 비교하였다. 결과: 만성 자궁경부염이 30명, CIN I이 9명, CIN II가 3명, CIN III가 12명이었다. Viral load가 100 RLU/PC 미만인 경우에는 CIN II 이상이 4명 있었으나 100 RLU/PC 이상인 경우에는 11명으로 유의하게 많았으며 (P=0.013) viral load가 100 RLU/PC 이상일 경우 100 RLU/PC 미만일 경우에 비해 ≥CIN II을 가질 상대위험도는 2.043 (95% CI, 1.216~3.432)으로 유의하게 높았다. 결론: Unsatisfactory colposcopy 소견이면서 ASCUS나 LSIL이 보고된 폐경여성에서 HPV viral load값이 높을 경우 ≥CIN II을 가질 위험이 높다.

Objective: To evaluate whether determination of the Human Papilloma Virus (HPV) viral load is helpful to predict the presence of high-grade cervical intraepithelial neoplasia (CIN) that requires aggressive treatment in menopausal women who have presented with an unsatisfactory colposcopic finding and ASCUS or LSIL. Methods: In menopausal women with ASCUS or LSIL and with who were positive for HPV, 54 women had diagnostic conization were analyzed retrospectively. We used the Hybrid Capture II method. We classified women in a low-risk group (chronic cervicitis, CIN I) and a high-risk group (≥CIN II) according to the pathological results of conization. We also classified patients into the HPV viral load <100 RLU/PC group and ≥100 RLU/PC group. We analyzed the relationship between the pathological results of conization and viral load. Results: For the conization, 30 women had chronic cervicitis, nine women had CIN I, three women had CIN II and 12 women had CIN III. In the low Hybrid Capture titer-group (<100 RLU/PC), four women had high risk ≥CIN II pathology but in the high Hybrid Capture titer-group (≥100 RLU/PC), 11 women had high risk pathology this finding was statistically significant (P=0.013). Compared to the low Hybrid Capture titer group, the relative risk of high grade CIN (≥CIN II) in the high Hybrid Capture titer group was 2.043 (95% CI, 1.216~3.432). Conclusions: For menopausal women with an unsatisfactory colposcopic finding and also have ASCUS or LSIL women with high HPV viral load might have tendency of ≥CIN II pathology.

Objective: To evaluate whether determination of the Human Papilloma Virus (HPV) viral load is helpful to predict the presence of high-grade cervical intraepithelial neoplasia (CIN) that requires aggressive treatment in menopausal women who have presented with an unsatisfactory colposcopic finding and ASCUS or LSIL. Methods: In menopausal women with ASCUS or LSIL and with who were positive for HPV, 54 women had diagnostic conization were analyzed retrospectively. We used the Hybrid Capture II method. We classified women in a low-risk group (chronic cervicitis, CIN I) and a high-risk group (≥CIN II) according to the pathological results of conization. We also classified patients into the HPV viral load <100 RLU/PC group and ≥100 RLU/PC group. We analyzed the relationship between the pathological results of conization and viral load. Results: For the conization, 30 women had chronic cervicitis, nine women had CIN I, three women had CIN II and 12 women had CIN III. In the low Hybrid Capture titer-group (<100 RLU/PC), four women had high risk ≥CIN II pathology but in the high Hybrid Capture titer-group (≥100 RLU/PC), 11 women had high risk pathology this finding was statistically significant (P=0.013). Compared to the low Hybrid Capture titer group, the relative risk of high grade CIN (≥CIN II) in the high Hybrid Capture titer group was 2.043 (95% CI, 1.216~3.432). Conclusions: For menopausal women with an unsatisfactory colposcopic finding and also have ASCUS or LSIL women with high HPV viral load might have tendency of ≥CIN II pathology.

Menopause, HPV viral load, CIN