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목적정상 산모와 전자간증 산모의 혈중 네프린 발현의 차이를 알아보고자 한다. 연구방법2008년 5월부터 9월까지 본 연구기관에서 분만한 산모 중 13명의 전자간증 산모와 7명의 정상 산모를 대상으로 하였고 Western blot을이용하여 혈중 네프린의 발현여부를 비교하였다. 결과두 군 간에 나이, 임신주수, 출산 당시 산모의 체중, 혈청 요소질소, 혈청 크레아티닌, 요중 크레아티닌 등은 차이가 없었다. 정상 산모에 비해 전자간증 산모에서 혈압(P＜0.001)과 혈중 soluble fms-like tyrosine kinase-1는 높았고(P = 0.002) 아기의 출생체중은 더 낮았다(P = 0.011). 혈청의 Western blot 결과, 전자간증 산모 13명 중 10명(76.9%), 정상 산모 7명 중 2명(28.6%)에서 혈중 네프린 단백이 확인되었다(P = 0.032). 결론혈중 네프린 단백의 발현 빈도가 정상 산모에 비해 전자간증 산모에서 더 높았다.
Objective Nephrin is one of the slit membrane proteins of podocytes in the kidney. It is known that the nephrin is shed in the urine in nephropathy accompanying proteinuira. So the aim of this study was to evaluate the difference in the serum nephrin expression between normal and preeclamptic pregnancies. Methods A total of 20 pregnant women from May to September 2008 who received prenatal care and underwent delivery at our institute participated in the study. The preeclamptic group includes 13 women diagnosed as preeclampsia and a normal group of 7. Their serum were collected before delivery and analyzed by Western blotting for comparing serum nephrin expression. Results There was no difference in age, body weight of pregnant women, blood urea nitrogen, serum creatinine, urine creatinine level and gestational age between two groups. However, preeclampsia group had significantly higher systolic and diastolic blood pressure (P <0.001), serum soluble fms-like tyrosine kinase-1 level (P = 0.002), and lower birth weight (P =0.011). In serum Western blot analysis, serum nephrin was detected in 10 of 13 in preeclampsia women (76.9%) but only in 2 of 7 (28.6%) in normal pregnancy women showing statistically significant difference (P =0.032). Conclusion A higher prevalence of nephrin expression in the maternal serum was found in the preeclampsia when compared to the normal pregnancy.
Objective Nephrin is one of the slit membrane proteins of podocytes in the kidney. It is known that the nephrin is shed in the urine in nephropathy accompanying proteinuira. So the aim of this study was to evaluate the difference in the serum nephrin expression between normal and preeclamptic pregnancies. Methods A total of 20 pregnant women from May to September 2008 who received prenatal care and underwent delivery at our institute participated in the study. The preeclamptic group includes 13 women diagnosed as preeclampsia and a normal group of 7. Their serum were collected before delivery and analyzed by Western blotting for comparing serum nephrin expression. Results There was no difference in age, body weight of pregnant women, blood urea nitrogen, serum creatinine, urine creatinine level and gestational age between two groups. However, preeclampsia group had significantly higher systolic and diastolic blood pressure (P <0.001), serum soluble fms-like tyrosine kinase-1 level (P = 0.002), and lower birth weight (P =0.011). In serum Western blot analysis, serum nephrin was detected in 10 of 13 in preeclampsia women (76.9%) but only in 2 of 7 (28.6%) in normal pregnancy women showing statistically significant difference (P =0.032). Conclusion A higher prevalence of nephrin expression in the maternal serum was found in the preeclampsia when compared to the normal pregnancy.
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Preeclampsia, Nephrin, Serum
