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Purpose: To investigate periorbital lipogranuloma cases that developed after autologous fat injection and to determinevarious treatment outcomes from these cases. Methods: This retrospective study involved 27 patients who presented with periocular mass (final diagnosis oflipogranuloma) and had history of facial autologous fat injection. The collected data included information onpatient sex, age, clinical presentation, number and site of fat injections, interval between injections, durationfrom injection to symptom onset, fat harvesting site, use of cryopreservation, and treatment outcome. Results: The most common presenting symptom was palpable mass (92.6%), followed by blepharoptosisand eyelid edema. The mean time from injection to symptom onset was 13.6 ± 29.2 months (range, 2 to 153months). Patients were managed by intralesional triamcinolone injection (six patients) and surgical excision(three patients); 18 patients were followed without treatment. Among the six patients who underwent intralesionaltriamcinolone injection, five showed complete resolution, and one showed partial resolution. Among the18 patients who were followed without management, three showed spontaneous resolution over a 5-monthfollow-up period. Conclusions: Lipogranuloma can develop in the eyelid after autologous fat injection into the face. Both surgicalexcision and intralesional triamcinolone injection yield relatively good outcomes. Simple observation can be agood option because spontaneous resolution can occur in a subset of patients.
