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Purpose: To evaluate prognostic factors affecting silicone tube intubation outcomes in Asian patients with lacrimaldrainage system stenosis. Methods: A retrospective review was conducted on the medical records of 822 patients (1,118 eyes) who hadundergone silicone tube intubation to treat lacrimal drainage system stenosis between January 2011 andDecember 2012. Patients were divided into two groups: a success group and a failure group. Success wasdefined as the disappearance of epiphora symptoms, normalization of tear meniscus height, and the easypassage of fluid without resistance on the postoperative syringing test. Patient and ocular parameters werecompared between the success and failure groups. Results: A total of 994 eyes of 727 patients were included in analyses. Patients had a mean follow-up period of34.11 ± 18.70 weeks. Silicone tube intubation was successful in 67.2% of participants. Significant differencesbetween the success and failure groups were found for age (p < 0.001), history of ipsilateral facial palsy (p= 0.028), follow-up period (p < 0.001), and degree of passage on the preoperative syringing test (p = 0.001). Only age (p < 0.001) and degree of passage on the preoperative syringing test (p = 0.002) remained significantlyassociated with silicone tube intubation success in multivariate analysis. Conclusions: Age was negatively associated with silicone tube intubation success in patients with lacrimaldrainage system stenosis. The success rate was higher in patients who showed easy passage of fluid withoutresistance on the preoperative syringing test. These factors should be considered by surgeons planning siliconetube intubation in patients with lacrimal drainage system stenosis.