목적 : 한국인의 병적 근시와 동반된 맥락막 신생혈관에서 verteporfin을 이용한 광역학 치료의 효과를 알아보고자 하였다. 대상과 방법 : 맥락막 신생혈관이 발생한 병적 근시 환자 중 광역학 치료를 받고 6개월 이상 추적 관찰이 가능하였던 39명 42안을 대상으로 의무기록을 후향적으로 분석하였으며 시술 전후 시력, 형광 안저 촬영 소견을 비교분석하였다. 결과 : 대상 환자들의 평균 연령은 39.6세였으며, 평균 추적 관찰 기간은 23.5개월이었다. 시력 변화는 시술 후 42안 중 호전 22안(55.4%), 유지 13안(30.9%), 악화 7안(16.7%)으로 나타났다. 형광 안저 촬영상 25안(59.5%)에서 형광 누출의 감소가 관찰 되었다. 결론 : 병적 근시와 동반된 맥락막 신생혈관에서 verteporfin을 이용한 광역학 치료는 한국인에 있어서도 병변의 안정화 및 시력 호전에 효과가 있으며 이러한 효과는 6개월 이상 지속되는 것으로 나타났다.

Purpose: To evaluate the effects of photodynamic therapy with verteporfin on visual acuity and fluorescein angiography in choroidal neovascularization (CNV) associated with pathologic myopia and to determine if this treatment could reproduce the results achieved in the Verteporfin in Photodynamic Therapy (VIP) Trial in Korean patients. Methods: Forty-two eyes of 39 patients with CNV secondary to pathologic myopia were included. A retrospective review of their clinical records and fluorescein angiography was done. The patients underwent photodynamic therapy with verteporfin and were followed up for more than 6 months after the therapy. The change in best corrected visual acuity (BCVA) and leakage in fluorescein angiography were evaluated. Results: The mean age of the patients was 39.6 and mean follow-up period was 23.5 months. The BCVA of the patients improved in 22 (52.4%) eyes, was unchanged in 13 (30.9%), and worsened in 7 (16.7%). The leakage in fluorescein angiography decreased in 25 (59.5%) eyes. Conclusions: Photodynamic therapy with verteporfin for myopic CNV in Korean patients appeared to be effective in stabilization of the lesions and improvement of visual acuity.

Purpose: To evaluate the effects of photodynamic therapy with verteporfin on visual acuity and fluorescein angiography in choroidal neovascularization (CNV) associated with pathologic myopia and to determine if this treatment could reproduce the results achieved in the Verteporfin in Photodynamic Therapy (VIP) Trial in Korean patients. Methods: Forty-two eyes of 39 patients with CNV secondary to pathologic myopia were included. A retrospective review of their clinical records and fluorescein angiography was done. The patients underwent photodynamic therapy with verteporfin and were followed up for more than 6 months after the therapy. The change in best corrected visual acuity (BCVA) and leakage in fluorescein angiography were evaluated. Results: The mean age of the patients was 39.6 and mean follow-up period was 23.5 months. The BCVA of the patients improved in 22 (52.4%) eyes, was unchanged in 13 (30.9%), and worsened in 7 (16.7%). The leakage in fluorescein angiography decreased in 25 (59.5%) eyes. Conclusions: Photodynamic therapy with verteporfin for myopic CNV in Korean patients appeared to be effective in stabilization of the lesions and improvement of visual acuity.

Choroidal neovascularization (CNV), Pathologic myopia, Photodynamic therapy (PDT)