목적 : 가토안에서 전방 내 트리암시놀론을 주입하고 각막에 미치는 영향을 알아보고자 하였다. 대상과 방법 : 백색가토의 전방에 트리암시놀론 아세토나이드 0.5, 1, 2 mg과 평형염액을 주입하고, 1, 3, 7, 14, 28일에 안압, 각막의 두께와 내피세포수를 측정하였고, 28일에 안구를 적출하여 조직검사를 하였다. 결과 : 각 군별 각막 두께의 차이는 없었고, 시간과 농도에 따른 차이도 없었다. 각막 내피 세포의 밀도는 각 군 및 시간과 농도별 차이는 없었으나, 다면성에서 2 mg 투여군이 3일까지 증가하였고, 다형성에서도 2 mg 투여군이 14일까지 감소하였다. 조직 검사상 각 군별 차이는 없었다. 결론 : 0.5~1 mg의 트리암시놀론 아세토나이드의 전방내 주입은 각막내피세포에 영향을 주지 않았다.

Purpose: To evaluate the safety and effects of intracameral triamcinolone acetonide injection in rabbit corneas. Methods: Triamcinolone acetonide in the amounts of 0.5, 1, and 2 mg was injected into the anterior chamber of rabbit eyes, and intraocular pressure, corneal thickness, and endothelial cell counts were evaluated on days 1, 3, 7, 14, and 28. Twenty-eight days after triamcinolone acetonide injection, the eyes were enucleated and examined after TUNEL staining. Results: No statistically significant differences were found among control, 0.5, and 1 mg triamcinolone- injected eyes in central corneal thickness, endothelial cell density, pleomorphism, and polymegathism. There was no difference between 2 mg triamcinolone-injected eyes and control eyes for corneal thickness and cell density, but there were statistically significant differences between these two groups for pleomorphism (p<0.05) and polymegathism (p<0.05). Conclusions: The results of this study suggested that intracameral injections of 0.5~1 mg of triamcinolone acetonide are beneficial and cause no toxic effects on corneas.

Purpose: To evaluate the safety and effects of intracameral triamcinolone acetonide injection in rabbit corneas. Methods: Triamcinolone acetonide in the amounts of 0.5, 1, and 2 mg was injected into the anterior chamber of rabbit eyes, and intraocular pressure, corneal thickness, and endothelial cell counts were evaluated on days 1, 3, 7, 14, and 28. Twenty-eight days after triamcinolone acetonide injection, the eyes were enucleated and examined after TUNEL staining. Results: No statistically significant differences were found among control, 0.5, and 1 mg triamcinolone- injected eyes in central corneal thickness, endothelial cell density, pleomorphism, and polymegathism. There was no difference between 2 mg triamcinolone-injected eyes and control eyes for corneal thickness and cell density, but there were statistically significant differences between these two groups for pleomorphism (p<0.05) and polymegathism (p<0.05). Conclusions: The results of this study suggested that intracameral injections of 0.5~1 mg of triamcinolone acetonide are beneficial and cause no toxic effects on corneas.