목적 : 갑상샘눈병증과 관련된 사시에서 사시상태의 자연경과를 장기간 관찰한 연구가 없어, 수술 없이 시간에 따른 사시의 자연경과를 알아보고자 하였다. 대상과 방법 : 갑상샘눈병증과 관련된 사시 또는 눈운동 제한이 있는 환자 중 수술을 하지 않고 6개월 이상 관찰한 환자를 대상으로 후향적으로 의무기록을 조사하였다. 관찰 기간 중 정면주시시 프리즘교대가림검사에서 10 프리즘디옵터(PD) 이상의 사시각의 변화를 보이는 경우를 의미 있는 변화로 정하고 그 변화 양상을 조사하였다. 결과 : 평균 23.8±17.7개월간 총 31명의 환자를 관찰한 결과 42%의 환자에서 사시각의 변화가 있었고 32%의 환자에서 수직 방향으로, 3%의 환자에서 수평 방향으로, 6%의 환자에서 수평과 수직방향으로 사시각이 변하였다. 경과 관찰 후 6개월 이내에 30%의 환자에서, 6～12개월 사이에 24%의 환자에서, 12～18개월 사이에 13%의 환자에서 사시각의 변화가 발생하였다. 결론 : 갑상샘눈병증에 의한 눈운동 제한이 발생한 환자는 시간이 경과할수록 사시각이 안정되는 양상을 보이나 일부에서는 12개월 이후에도 사시각이 안정되지 않았다. 사시각 변화는 수평방향보다 수직방향으로의 변화가 빈번하였다.

Purpose: This study investigated the natural course of strabismus associated with thyroid ophthalmopathy. Methods: A retrospective review was performed on the medical records of 31 patients with strabismus associated with thyroid ophthalmopathy who had been followed up for more than 6 months and had not received surgery. For the purpose of this study, a significant change of deviation angle was defined as more than 10 prism diopters in the primary position. Results: Forty-two percent of patients showed a significant change in deviation angle during the observation period of 23.8±17.7 months. The direction of the change was vertical in 32%, horizontal in 3%, and vertical and horizontal in 6% of patients. A significant change of deviation angle developed in 30% of patients within 6 months from the initial ophthalmologic examination, in 24% between 6 and 12 months, and in 13% of patients between 12 and 18 months from the initial examination. Conclusions: Although the deviation angle of strabismus associated with thyroid ophthalmopathy tended to stabilize with time, it nonetheless was susceptible to change even 12 months after the initial ophthalmologic examination. In addition, a vertical change in the deviation angle was more frequent than a horizontal change

Purpose: This study investigated the natural course of strabismus associated with thyroid ophthalmopathy. Methods: A retrospective review was performed on the medical records of 31 patients with strabismus associated with thyroid ophthalmopathy who had been followed up for more than 6 months and had not received surgery. For the purpose of this study, a significant change of deviation angle was defined as more than 10 prism diopters in the primary position. Results: Forty-two percent of patients showed a significant change in deviation angle during the observation period of 23.8±17.7 months. The direction of the change was vertical in 32%, horizontal in 3%, and vertical and horizontal in 6% of patients. A significant change of deviation angle developed in 30% of patients within 6 months from the initial ophthalmologic examination, in 24% between 6 and 12 months, and in 13% of patients between 12 and 18 months from the initial examination. Conclusions: Although the deviation angle of strabismus associated with thyroid ophthalmopathy tended to stabilize with time, it nonetheless was susceptible to change even 12 months after the initial ophthalmologic examination. In addition, a vertical change in the deviation angle was more frequent than a horizontal change

Natural course, Strabismus, Thyroid ophthalmopathy