목적 : 한국인 앞허혈시신경병증의 위험인자를 분석해보고자 하였다. 대상과 방법 : 앞허혈시신경병증으로 진단받은 한국인 48명 55안의 의무기록을 후향적으로 분석하여 나이, 성별, 전신질환, 과거력, 사회력, 혈액검사 소견, 24시간 혈압, 반대편 눈의 안저 소견 등을 조사하였다. 결과 : 대상 환자의 평균연령은 59.4세(36～80)였고, 45세 미만이 6명(12.5%), 45～64세가 18명(37.5%), 65세 이상이 24명(50.0%)이었다. 남자가 24명(50.0%), 여자가 24명(50.0%)이었다. 29명(60.4%)에서 고혈압, 당뇨, 뇌혈관질환, 편두통, 심장질환 등의 전신질환이 동반되었고 그 중 고혈압이 19명(65.5%)으로 가장 많았다. 흡연력이 있는 9명(18.8%)의 평균연령은 50.6세였다. 백내장 수술 후 발생한 경우가 4명이었다. 혈액검사 상 콜레스테롤치가 25명 중 17명(68.0%)에서 높았다. 24시간 혈압측정은 4명에서 시행되었는데 모두에서 밤의 혈압이 낮보다 낮았다. 반대측 정상안의 안저검사 결과 시신경 유두함몰비가 0.2 이하인 경우가 단안이 침범된 41안 중 28안(68.3%)이었다. 결론 : 한국인 앞허혈시신경병증 환자의 60% 이상에서 고혈압과 고지질혈증의 전신질환과 0.2 이하의 시신경 유두함몰비가 관찰되어 이 세 가지가 중요한 위험인자였다.

Purpose: To analyze the risk factors of Korean patients with anterior ischemic optic neuropathy (AION). Methods: Medical records of 48 Korean patients (24 men, 24 women) who were diagnosed as having AION were retrospectively reviewed and the risk factors of AION including age, sex, associated systemic disease, past medical history, social history, hematologic findings, 24-hour blood pressure monitoring, and optic disc of the clinically normal fellow eye, were analyzed. Results: The mean age of the 48 patients was 59.4 years (range, 36~80 years). There were 6 patients (12.5%) less than 45 years of age, 18 patients (37.5%) of 45 to 65 years of age, and 24 patients (50.0%) more than 65 years of age. There were 29 patients (60.4%) with associated systemic diseases such as hypertension (65.5%), diabetes mellitus, cerebrovascular disease, migraine, and heart disease with a decreasing order. Nine patients (18.8%) with a mean age of 50.6 years were smoker. Four patients developed AION after a cataract operation. There were 17 (68.0%) out of 25 patients with an increased level of cholesterol. Four patients whose 24-hour blood pressure was monitored showed that their blood pressure in night was lower than that in the day time. A cup disc ratio less than 0.2 was observed in 28 contralateral eyes (68.3%) of 41 patients with unilateral AION. Conclusions: Hypertension, high cholesterol and decreased cup-to-disc ratio were observed in more than 60% of the Korean patients with AION, thereby composed the major risk factors.

Purpose: To analyze the risk factors of Korean patients with anterior ischemic optic neuropathy (AION). Methods: Medical records of 48 Korean patients (24 men, 24 women) who were diagnosed as having AION were retrospectively reviewed and the risk factors of AION including age, sex, associated systemic disease, past medical history, social history, hematologic findings, 24-hour blood pressure monitoring, and optic disc of the clinically normal fellow eye, were analyzed. Results: The mean age of the 48 patients was 59.4 years (range, 36~80 years). There were 6 patients (12.5%) less than 45 years of age, 18 patients (37.5%) of 45 to 65 years of age, and 24 patients (50.0%) more than 65 years of age. There were 29 patients (60.4%) with associated systemic diseases such as hypertension (65.5%), diabetes mellitus, cerebrovascular disease, migraine, and heart disease with a decreasing order. Nine patients (18.8%) with a mean age of 50.6 years were smoker. Four patients developed AION after a cataract operation. There were 17 (68.0%) out of 25 patients with an increased level of cholesterol. Four patients whose 24-hour blood pressure was monitored showed that their blood pressure in night was lower than that in the day time. A cup disc ratio less than 0.2 was observed in 28 contralateral eyes (68.3%) of 41 patients with unilateral AION. Conclusions: Hypertension, high cholesterol and decreased cup-to-disc ratio were observed in more than 60% of the Korean patients with AION, thereby composed the major risk factors.

Anterior ischemic optic neuropathy, Cholesterol, Hypertension, Disc shape, Risk factors