초록 열기/닫기 버튼
저자들은 결핵이 동반된 HIV감염자에서 HAART 시행 후 발열, 림프절종대, 방사선학적 이상소견 등의 전신적 염증반응이 나타나 스테로이드를 사용하여 이를 효과적으로 치료한 2예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.
Highly active antiretroviral therapy for HIV infection has led to substantial reduction in AIDS associated morbidity and mortality. Systemic inflammatory reactions after the initiation of HAART (highly active antiretroviral therapy) have recently been described in HIV infected patients. The pathogenesis of systemic inflammatory reaction after HAART has not yet been clearly explained, but immune restoration after HAART may explain this phenomenon. We report two cases of systemic inflammatory reactions after starting HAART in HIV-infected patients. In each cases, 5 or 18 days after starting combination antiretroviral therapy, spiking fever and infiltration on chest Xray were developed. The etiology of fever such as opportunistic infection, drug reaction, noncompliance, or malabsorption were evaluated, but cause for clinical deterioration was not found. We concluded that this phenomenon was systemic inflammatory reaction after HAART and we overcame the clinical deterioration by steroid use.(Korean J Med 62:313-319, 2002)
Highly active antiretroviral therapy for HIV infection has led to substantial reduction in AIDS associated morbidity and mortality. Systemic inflammatory reactions after the initiation of HAART (highly active antiretroviral therapy) have recently been described in HIV infected patients. The pathogenesis of systemic inflammatory reaction after HAART has not yet been clearly explained, but immune restoration after HAART may explain this phenomenon. We report two cases of systemic inflammatory reactions after starting HAART in HIV-infected patients. In each cases, 5 or 18 days after starting combination antiretroviral therapy, spiking fever and infiltration on chest Xray were developed. The etiology of fever such as opportunistic infection, drug reaction, noncompliance, or malabsorption were evaluated, but cause for clinical deterioration was not found. We concluded that this phenomenon was systemic inflammatory reaction after HAART and we overcame the clinical deterioration by steroid use.(Korean J Med 62:313-319, 2002)
키워드열기/닫기 버튼
HIV, HIV infections, Acquired immunodeficiency syndrome, Antiretroviral therapy, highly active
