초록 열기/닫기 버튼
The coexpression of cortical and medullary features in a single adrenal cortical cell has been recognized, leading to terms such as cortico-medullary cells. Here, we reported a case of adrenocortical adenoma consisting of cortico-medullary cells that clinically mimicked pheochromocytoma. A 52-year-old woman was admitted to our hospital complaining of an 8-month history of paroxysmal palpitation with refractory hypertension. A 24-hour urine study revealed increased norepinephrine and metanephrine levels. Computed tomography of the abdomen revealed a 1.0×0.9-cm mass in the left adrenal gland. The patient subsequently underwent unilateral laparoscopic adrenalectomy for a presumptive pheochromocytoma. Light microscopic findings of the left adrenal mass indicated an adrenocortical adenoma, but electron microscopy identified lipid vacuoles and smooth endoplasmic reticulum, along with dense core neurosecretory granules, so-called cortico-medullary cells. This is the first report of the detection of cortico-medullary cells in adrenocortical adenoma presenting as pheochromocytoma in Korea. (Korean J Med 75:479-483, 2008)
하나의 부신 세포에서 피질과 수질의 특징이 함께 공존하는 피질-수질세포에 관한 예들이 1960년대 이후로 보고되어 왔다. 저자들은 갈색세포종의 임상적 특징을 보이지만, 수술 후 갈색세포종의 임상증상과 생화학적 특징이 정상으로 회복되었으며 광학현미경상 부신 피질 선종의 특징을 보이지만, 면역조직화학 검사와 전자현미경 검사에서 피질-수질세포를 보인 1예를 경험하였기에 문헌고찰과 함께 국내 처음으로 보고하는 바이다.
키워드열기/닫기 버튼
Hypertension; Pheochromocytoma; Adrenocortical adenoma
