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This paper reports a case of primary squamous cell carcinoma (SCC) of the liver. The patient had a large mass between the left lateral segment of the liver and the lesser curvature of the stomach on computed tomography. Ultrasonography-guided fine needle aspiration of the mass was suggestive of a well-differentiated SCC. A left lobectomy of the liver and wedge resection of the stomach were performed. The pathology showed positive immunoreactivity for cytokeratin 19 (CK19), carcinoma-embryonic antigen and high-molecular-weight cytokeratin, and negative immunoreactivity for CK8, CK18 and hepatic-specific antigen.