초록 열기/닫기 버튼
향후 우리나라에서 진정한 A1C의 당뇨병 진단기준 설정을 하기 위해서는 다음의 연구들이 필요할 것이다. 첫째, 본 연구를 포함하여 현재까지 시행되었던 A1C와 경구당부하검사 결과의 임계값 관련 연구들을 집약한 메타 분석을 해야 할 것이며 둘째, 지역사회 코호트 기반 당뇨병 역학연구에서 시행된 전향적 연구결과를 바탕으로 당뇨병 만성합병증 발생 증가에 해당하는 A1C 농도를 결정해야 할 것이다.
Glycated hemoglobin (HbA_1c, A1C) is a widely used marker of chronic glycemia, reflecting average blood glucose levels over a 2- to 3-month period of time. Recently role of A1C in diagnosing diabetes has been extensively reviewed and International Expert Committee and American diabetes Association recommended the use of the A1C test to diagnose diabetes, with a threshold of ≥6.5%. The diagnostic A1C cut point of 6.5% is associated with an inflection point for retinopathy prevalence, as are the diagnostic thresholds for plasma glucose levels. But A1C levels vary with different races. Meta-analyses for previous studies regarding A1C cut off value for plasma glucose in Koreans and determination of A1C cut point based on the development of diabetic microvascular complications in community based cohorts should be performed to establish diagnostic A1C cut point in Korean population. (Korean J Med 2011;80:288-290)
키워드열기/닫기 버튼
HbA_1c; Diabetes; Diagnosis
